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EC Number
Localization
Commentary
GeneOntology No.
Reference
2.4.1.221
cell surface
cell surface accumulation of Notch in ofut1 mutant cells
GO:0009986
AmiGO
QuickGO
704718
2.4.1.221
cell surface
OFUT1 associates with Notch at the cell surface and promotes the constitutive endocytosis of Notch receptors
GO:0009986
AmiGO
QuickGO
704343
2.4.1.221
cell surface
OFUT1 may be a chaperone of Notch that is necessary for retaining Notch at the cell surface once it has traversed the secretory pathway
GO:0009986
AmiGO
QuickGO
703986
2.4.1.221
endoplasmic reticulum
-
GO:0005783
AmiGO
QuickGO
659448
,
703986
,
723541
,
759099
,
759834
2.4.1.221
endoplasmic reticulum
Ofut1 acts as a chaperone in the endoplasmic reticulum to promote the proper folding of the epidermal growth factor-like repeats of Notch, thereby ensuring its correct cell-surface localization and ligand-binding activity
GO:0005783
AmiGO
QuickGO
704718
2.4.1.221
endoplasmic reticulum
OFUT1 is required for the correct folding of Notch receptors in the endoplasmic reticulum and their subsequent trafficking to the cell surface
GO:0005783
AmiGO
QuickGO
704343
2.4.1.221
endoplasmic reticulum
OFUT1 may be a chaperone of Notch that is necessary for escorting Notch out of the endoplasmic reticulum
GO:0005783
AmiGO
QuickGO
703986
2.4.1.221
endoplasmic reticulum
Pofut1 mainly colocalizes with GRP94, an endoplasmic reticulum chaperone
GO:0005783
AmiGO
QuickGO
736799
2.4.1.221
endoplasmic reticulum
retention in the ER is required for normal OFUT1 function in vivo
GO:0005783
AmiGO
QuickGO
677126
2.4.1.221
endoplasmic reticulum lumen
-
GO:0005788
AmiGO
QuickGO
722090
,
722696
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