EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   2.3.1.B43 | cytoplasm |
- |
GO:0005737 AmiGO QuickGO |
756522, 757084 |
| 2.3.1.B43 | cytoplasm |
mainly distributed in the cytoplasm of Purkinje cells |
GO:0005737 AmiGO QuickGO |
730103 |
| 2.3.1.B43 | cytoplasm |
SIRT5 isoforms (i.e., SIRT5iso1 and SIRT5iso2) are encoded by the human SIRT5 gene. Their C-termini slightly differ from each other. Although both isoforms contain cleavable mitochondrial targeting signals at their N-termini,it is found that the cleaved SIRT5iso2 is localized mainly in mitochondria, whereas the cleaved SIRT5iso1 is localized in both mitochondria and cytoplasm. The cytoplasmic localization of cleaved SIRT5iso1 is dependent on the SIRT5iso1-specific C-terminus |
GO:0005737 AmiGO QuickGO |
729801 |
| 2.3.1.B43 | cytoplasm |
SIRT5 isozyme 4 is mainly localized in the cytoplasm |
GO:0005737 AmiGO QuickGO |
755970 |
| 2.3.1.B43 | mitochondrial inner membrane |
SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin |
GO:0005743 AmiGO QuickGO |
757175 |
| 2.3.1.B43 | mitochondrial matrix |
- |
GO:0005759 AmiGO QuickGO |
703149, 728932, 757590 |
| 2.3.1.B43 | mitochondrial matrix |
predominantly |
GO:0005759 AmiGO QuickGO |
756522 |
| 2.3.1.B43 | mitochondrion |
- |
GO:0005739 AmiGO QuickGO |
-, 729556, 729732, 730922, 731010, 755788, 756010, 756393, 756563, 756680, 757084, 757175, 757184, 757350, 757400, 758247 |
| 2.3.1.B43 | mitochondrion |
primarily |
GO:0005739 AmiGO QuickGO |
756555 |
| 2.3.1.B43 | mitochondrion |
Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix |
GO:0005739 AmiGO QuickGO |
730205 |
