EC Number |
Recommended Name |
Localization |
GeneOntology No. |
Reference |
---|
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
mitochondrial inner membrane |
enzyme E2 overexpression or disruption of mitochondrial membrane potential causes enzyme E2 release from mitochondria to cytoplasm where it is degraded |
GO:0005743 AmiGO QuickGO |
656265 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
724302, 725511 |
2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
636998 |
2.3.1.37 | 5-aminolevulinate synthase |
mitochondrial inner membrane |
loosely bound |
GO:0005743 AmiGO QuickGO |
486818 |
2.1.2.10 | aminomethyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
391993, 706478 |
2.8.2.B1 | APS sulfotransferase |
mitochondrial inner membrane |
periplasmic side |
GO:0005743 AmiGO QuickGO |
289091 |
7.4.2.5 | bacterial ABC-type protein transporter |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
670487 |
1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system |
mitochondrial inner membrane |
human BCKD complex is likely located on the matrix side of the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
762596 |
6.3.4.16 | carbamoyl-phosphate synthase (ammonia) |
mitochondrial inner membrane |
contained completely within the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
1468 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
486541, 486544, 703967, 705753 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
CPT2 |
GO:0005743 AmiGO QuickGO |
659899 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
enzyme from outer and from inner membrane have different properties |
GO:0005743 AmiGO QuickGO |
486535, 486536 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
enzyme is present on both sides of the inner membrane, not on the outer membrane |
GO:0005743 AmiGO QuickGO |
486537, 486557 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
inner face of inner membrane |
GO:0005743 AmiGO QuickGO |
486552, 486553, 486555, 486558, 486561, 486566 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
outer face of inner membrane |
GO:0005743 AmiGO QuickGO |
486523, 486538, 486553, 486555, 486556 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
745596 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 285415, 285416, 285417, 285419, 285422, 285423, 285424, 285425, 285427, 285428, 285431, 285432, 703100, 712924, 725962 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
adrenodoxin reductase and adrenodoxin are peripheral proteins on matrix side of inner membrane, P-450scc is integral membrane protein |
GO:0005743 AmiGO QuickGO |
285413, 285414 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
electron carriers and P-450 liquid-bound within mitochondrion |
GO:0005743 AmiGO QuickGO |
285418 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
inner membrane |
GO:0005743 AmiGO QuickGO |
285426, 285429, 285430, 285433 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
integral to membrane |
GO:0005743 AmiGO QuickGO |
285412, 285414, 285421 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
matrix side |
GO:0005743 AmiGO QuickGO |
285420, 285429 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
membrane topology, overview |
GO:0005743 AmiGO QuickGO |
673298 |
1.1.99.1 | choline dehydrogenase |
mitochondrial inner membrane |
a nuclear-encoded, membrane-located, mitochondrial enzyme |
GO:0005743 AmiGO QuickGO |
741756 |
1.1.99.1 | choline dehydrogenase |
mitochondrial inner membrane |
a nuclear-encoded, membrane-located, mitochondrial enzyme. Human CHD is not an integral membrane protein, but associated to the membrane |
GO:0005743 AmiGO QuickGO |
741756 |
2.3.3.16 | citrate synthase (unknown stereospecificity) |
mitochondrial inner membrane |
45% of CS II is bound to mitochondrial inner membrane and 2% of CS I |
GO:0005743 AmiGO QuickGO |
488068 |
2.7.3.2 | creatine kinase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
737427 |
7.1.1.9 | cytochrome-c oxidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 692708, 693098 |
3.4.99.B2 | D-aspartyl endopeptidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
667380, 695517 |
1.1.2.4 | D-lactate dehydrogenase (cytochrome) |
mitochondrial inner membrane |
the enzyme is located on the inner face of the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
740447 |
2.3.1.12 | dihydrolipoyllysine-residue acetyltransferase |
mitochondrial inner membrane |
pyruvate dehydrogenase complex bound to inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
348927 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
712071 |
5.6.2.3 | DNA 5'-3' helicase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
757877 |
3.6.5.5 | dynamin GTPase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
689227 |
3.6.5.5 | dynamin GTPase |
mitochondrial inner membrane |
Drp1 assembles into large complexes at future scission sites on the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
686382 |
1.5.5.1 | electron-transferring-flavoprotein dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
726447 |
1.5.5.1 | electron-transferring-flavoprotein dehydrogenase |
mitochondrial inner membrane |
bound to via ubiquinone binding domain, overview |
GO:0005743 AmiGO QuickGO |
724410 |
4.2.1.17 | enoyl-CoA hydratase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
714222 |
1.8.5.8 | eukaryotic sulfide quinone oxidoreductase |
mitochondrial inner membrane |
membrane-anchored |
GO:0005743 AmiGO QuickGO |
764977 |
1.8.5.8 | eukaryotic sulfide quinone oxidoreductase |
mitochondrial inner membrane |
mitochondrial inner membrane-anchored enzyme |
GO:0005743 AmiGO QuickGO |
764484 |
1.3.99.32 | glutaryl-CoA dehydrogenase (acceptor) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
712280 |
1.3.8.6 | glutaryl-CoA dehydrogenase (ETF) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
712280 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
486362, 486372 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
mitochondrial inner membrane |
cytoplasmic side of inner membrane |
GO:0005743 AmiGO QuickGO |
486381 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
mitochondrial inner membrane |
significant acyltransferase activity in inner membrane |
GO:0005743 AmiGO QuickGO |
486377 |
1.1.5.3 | glycerol-3-phosphate dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 723350 |
1.1.5.3 | glycerol-3-phosphate dehydrogenase |
mitochondrial inner membrane |
the active site of mGPDH faces the mitochondrial intermembrane space, as does its calcium-sensitive EF-hand domain |
GO:0005743 AmiGO QuickGO |
-, 741302 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
667798 |
2.1.4.1 | glycine amidinotransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
485975 |
7.1.2.2 | H+-transporting two-sector ATPase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
686272 |
7.1.2.2 | H+-transporting two-sector ATPase |
mitochondrial inner membrane |
oligomerization of ATP synthase is critical for the morphology of the inner mitochondrial membrane because it supports the generation of tubular cristae membrane domains, overview. Association of individual F1Fo-ATP synthase complexes is mediated by the membrane-embedded Fo-part |
GO:0005743 AmiGO QuickGO |
712982 |
7.1.2.2 | H+-transporting two-sector ATPase |
mitochondrial inner membrane |
the enzyme is found in monomeric, dimeric and higher oligomeric forms in the inner mitochondrial membrane. Two small proteins of the membrane-embedded Fo-domain subunits e and g are dimer-specific subunits of yeast ATP synthase and are required for stabilization of the dimers |
GO:0005743 AmiGO QuickGO |
712746 |
7.1.2.2 | H+-transporting two-sector ATPase |
mitochondrial inner membrane |
the F1 moiety of the complex protrudes at the inner side of the membrane, the Fo sector spans the membrane reaching the outer side |
GO:0005743 AmiGO QuickGO |
696051 |
1.17.99.9 | heme a synthase |
mitochondrial inner membrane |
Cox15p is a constituent of the mitochondrial inner membrane |
GO:0005743 AmiGO QuickGO |
759454 |
4.4.1.17 | Holocytochrome-c synthase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
94056, 94057, 94058 |
4.4.1.17 | Holocytochrome-c synthase |
mitochondrial inner membrane |
integral membrane protein, facing cytoplasmic surface |
GO:0005743 AmiGO QuickGO |
94055 |
4.4.1.17 | Holocytochrome-c synthase |
mitochondrial inner membrane |
separation of mitochondrial inner and outer membrane on a sucrose gradient |
GO:0005743 AmiGO QuickGO |
665678 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
653183, 681916, 692511, 694091 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
integral, a large domain is exposed to the intermembrane space |
GO:0005743 AmiGO QuickGO |
650958 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
integral, catalytic site facing the intermembrane space |
GO:0005743 AmiGO QuickGO |
649814 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
only subunit type Yme1p spans the membrane once, integral, catalytic site facing the inter membrane space |
GO:0005743 AmiGO QuickGO |
649814 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
outer surface of |
GO:0005743 AmiGO QuickGO |
653335 |
2.6.1.7 | kynurenine-oxoglutarate transaminase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 636623 |
1.3.2.3 | L-galactonolactone dehydrogenase |
mitochondrial inner membrane |
GLDH behaves as an integral protein of the inner membrane facing the intermembrane space |
GO:0005743 AmiGO QuickGO |
-, 746093 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
286269 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
653198, 681927, 711611, 712130, 712541, 712981, 713349, 718997 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
both subunit types span the membrane twice, integral, active at the matrix side of the inner membrane |
GO:0005743 AmiGO QuickGO |
649814 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
inner side, exposes catalytic sites to the mitochondrial matrix |
GO:0005743 AmiGO QuickGO |
650958 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
integral, active at the matrix side of the inner membrane |
GO:0005743 AmiGO QuickGO |
649814, 650372 |
6.4.1.4 | methylcrotonoyl-CoA carboxylase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
1883, 1885 |
7.4.2.3 | mitochondrial protein-transporting ATPase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
686245, 687560, 689911, 700155 |
1.6.1.3 | NAD(P)+ transhydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
724928 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 658473, 696513, 724435, 725068, 725514 |
7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
724383, 724564, 725003, 725142, 725491 |
7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) |
mitochondrial inner membrane |
activities of submitochondrial fragments from heart and brain, overview |
GO:0005743 AmiGO QuickGO |
724252 |
3.6.4.10 | non-chaperonin molecular chaperone ATPase |
mitochondrial inner membrane |
associated to on the matrix side |
GO:0005743 AmiGO QuickGO |
734351 |
2.7.4.6 | nucleoside-diphosphate kinase |
mitochondrial inner membrane |
NDPK is attached to the outer side of the inner the membrane |
GO:0005743 AmiGO QuickGO |
672407 |
2.7.4.6 | nucleoside-diphosphate kinase |
mitochondrial inner membrane |
structural basis of NDPK-D/mitochondrial membrane interactions via binding of cardiolipin, overview |
GO:0005743 AmiGO QuickGO |
693134 |
2.7.4.6 | nucleoside-diphosphate kinase |
mitochondrial inner membrane |
structural basis of NDPK-D/mitochondrial membrane interactions, overview |
GO:0005743 AmiGO QuickGO |
693134 |
1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
656596 |
1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) |
mitochondrial inner membrane |
associated with |
GO:0005743 AmiGO QuickGO |
654699 |
7.2.2.14 | P-type Mg2+ transporter |
mitochondrial inner membrane |
Mrs2p |
GO:0005743 AmiGO QuickGO |
689037 |
7.2.2.14 | P-type Mg2+ transporter |
mitochondrial inner membrane |
Mrs2p contains two adjacent transmembrane domains near the C terminus of Mrs2p one of which ends with a F/Y-G-M-N motif |
GO:0005743 AmiGO QuickGO |
686644 |
7.6.2.1 | P-type phospholipid transporter |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
684674 |
2.7.7.41 | phosphatidate cytidylyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
738000 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
4765, 4771, 4782, 4783, 4788 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
exclusively in the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
4779, 4791 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
external side of the inner membrane |
GO:0005743 AmiGO QuickGO |
4777 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
inner membrane |
GO:0005743 AmiGO QuickGO |
4776, 4783 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
membrane |
GO:0005743 AmiGO QuickGO |
4761, 4776 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 764207 |
1.5.5.2 | proline dehydrogenase |
mitochondrial inner membrane |
co-localization with the electron transport chain on the inner membrane of the mitochondria |
GO:0005743 AmiGO QuickGO |
741588 |
1.5.5.2 | proline dehydrogenase |
mitochondrial inner membrane |
TcPRODH is associated with the mitochondrial inner membrane, identification of a predicted N-terminal mitochondrial targeting signal, followed by a putative transmembrane alpha helix spanning domain |
GO:0005743 AmiGO QuickGO |
-, 743635 |
1.5.99.B2 | proline dehydrogenase (acceptor) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
699706, 742204 |
2.3.1.B43 | protein-lysine desuccinylase (NAD+) |
mitochondrial inner membrane |
SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin |
GO:0005743 AmiGO QuickGO |
757175 |
4.98.1.1 | protoporphyrin ferrochelatase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
729221, 729863 |
1.3.3.4 | protoporphyrinogen oxidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
654874 |
1.3.3.4 | protoporphyrinogen oxidase |
mitochondrial inner membrane |
analysis of mitochondrial targeting sequences of wild-type and mutant enzymes, overview |
GO:0005743 AmiGO QuickGO |
655497 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
672935, 674605, 676262 |
6.4.1.1 | pyruvate carboxylase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
1774, 649667 |