EC Number |
Recommended Name |
Localization |
GeneOntology No. |
Reference |
---|
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
724302, 725511 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
286269 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
667798 |
1.1.2.4 | D-lactate dehydrogenase (cytochrome) |
mitochondrial inner membrane |
the enzyme is located on the inner face of the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
740447 |
1.1.5.3 | glycerol-3-phosphate dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 723350 |
1.1.5.3 | glycerol-3-phosphate dehydrogenase |
mitochondrial inner membrane |
the active site of mGPDH faces the mitochondrial intermembrane space, as does its calcium-sensitive EF-hand domain |
GO:0005743 AmiGO QuickGO |
-, 741302 |
1.1.99.1 | choline dehydrogenase |
mitochondrial inner membrane |
a nuclear-encoded, membrane-located, mitochondrial enzyme |
GO:0005743 AmiGO QuickGO |
741756 |
1.1.99.1 | choline dehydrogenase |
mitochondrial inner membrane |
a nuclear-encoded, membrane-located, mitochondrial enzyme. Human CHD is not an integral membrane protein, but associated to the membrane |
GO:0005743 AmiGO QuickGO |
741756 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 764207 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
745596 |
1.14.14.1 | unspecific monooxygenase |
mitochondrial inner membrane |
CYP24A1 and CYP27A1 |
GO:0005743 AmiGO QuickGO |
701574 |
1.14.15.4 | steroid 11beta-monooxygenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
726012 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 285415, 285416, 285417, 285419, 285422, 285423, 285424, 285425, 285427, 285428, 285431, 285432, 703100, 712924, 725962 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
adrenodoxin reductase and adrenodoxin are peripheral proteins on matrix side of inner membrane, P-450scc is integral membrane protein |
GO:0005743 AmiGO QuickGO |
285413, 285414 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
electron carriers and P-450 liquid-bound within mitochondrion |
GO:0005743 AmiGO QuickGO |
285418 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
inner membrane |
GO:0005743 AmiGO QuickGO |
285426, 285429, 285430, 285433 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
integral to membrane |
GO:0005743 AmiGO QuickGO |
285412, 285414, 285421 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
matrix side |
GO:0005743 AmiGO QuickGO |
285420, 285429 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
mitochondrial inner membrane |
membrane topology, overview |
GO:0005743 AmiGO QuickGO |
673298 |
1.17.99.9 | heme a synthase |
mitochondrial inner membrane |
Cox15p is a constituent of the mitochondrial inner membrane |
GO:0005743 AmiGO QuickGO |
759454 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
mitochondrial inner membrane |
enzyme E2 overexpression or disruption of mitochondrial membrane potential causes enzyme E2 release from mitochondria to cytoplasm where it is degraded |
GO:0005743 AmiGO QuickGO |
656265 |
1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system |
mitochondrial inner membrane |
human BCKD complex is likely located on the matrix side of the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
762596 |
1.2.1.36 | retinal dehydrogenase |
mitochondrial inner membrane |
outer side |
GO:0005743 AmiGO QuickGO |
686690 |
1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
656596 |
1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) |
mitochondrial inner membrane |
associated with |
GO:0005743 AmiGO QuickGO |
654699 |
1.3.2.3 | L-galactonolactone dehydrogenase |
mitochondrial inner membrane |
GLDH behaves as an integral protein of the inner membrane facing the intermembrane space |
GO:0005743 AmiGO QuickGO |
-, 746093 |
1.3.3.4 | protoporphyrinogen oxidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
654874 |
1.3.3.4 | protoporphyrinogen oxidase |
mitochondrial inner membrane |
analysis of mitochondrial targeting sequences of wild-type and mutant enzymes, overview |
GO:0005743 AmiGO QuickGO |
655497 |
1.3.5.1 | succinate dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 686649, 712018, 713193, 763269 |
1.3.5.1 | succinate dehydrogenase |
mitochondrial inner membrane |
the catalytic domain (SDH1 and 2) is extrinsic on the matrix side, while the anchor subunits (SDH3 and 4) are intrinsic transmembrane proteins, allowing transfer of the electrons from succinate in the mitochondrial matrix to ubiquinone in the inner membrane |
GO:0005743 AmiGO QuickGO |
762895 |
1.3.5.1 | succinate dehydrogenase |
mitochondrial inner membrane |
the catalytic domain (SDHA and B) is extrinsic on the matrix side, while the anchor subunits (SDHC and D) are intrinsic transmembrane proteins, allowing transfer of the electrons from succinate in the mitochondrial matrix to ubiquinone in the inner membrane |
GO:0005743 AmiGO QuickGO |
762895 |
1.3.5.1 | succinate dehydrogenase |
mitochondrial inner membrane |
the membrane domain consists of two subunits SdhC and SdhD. The membrane domain contains a bound heme b moiety at the subunit interface with SdhC and SdhD each providing one of the two axial His ligands |
GO:0005743 AmiGO QuickGO |
712976 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
712071 |
1.3.8.6 | glutaryl-CoA dehydrogenase (ETF) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
712280 |
1.3.99.32 | glutaryl-CoA dehydrogenase (acceptor) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
712280 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
672935, 674605, 676262 |
1.5.5.1 | electron-transferring-flavoprotein dehydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
726447 |
1.5.5.1 | electron-transferring-flavoprotein dehydrogenase |
mitochondrial inner membrane |
bound to via ubiquinone binding domain, overview |
GO:0005743 AmiGO QuickGO |
724410 |
1.5.5.2 | proline dehydrogenase |
mitochondrial inner membrane |
co-localization with the electron transport chain on the inner membrane of the mitochondria |
GO:0005743 AmiGO QuickGO |
741588 |
1.5.5.2 | proline dehydrogenase |
mitochondrial inner membrane |
TcPRODH is associated with the mitochondrial inner membrane, identification of a predicted N-terminal mitochondrial targeting signal, followed by a putative transmembrane alpha helix spanning domain |
GO:0005743 AmiGO QuickGO |
-, 743635 |
1.5.99.B2 | proline dehydrogenase (acceptor) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
699706, 742204 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 658473, 696513, 724435, 725068, 725514 |
1.6.1.3 | NAD(P)+ transhydrogenase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
724928 |
1.8.5.8 | eukaryotic sulfide quinone oxidoreductase |
mitochondrial inner membrane |
membrane-anchored |
GO:0005743 AmiGO QuickGO |
764977 |
1.8.5.8 | eukaryotic sulfide quinone oxidoreductase |
mitochondrial inner membrane |
mitochondrial inner membrane-anchored enzyme |
GO:0005743 AmiGO QuickGO |
764484 |
2.1.1.41 | sterol 24-C-methyltransferase |
mitochondrial inner membrane |
some activity |
GO:0005743 AmiGO QuickGO |
485327, 485328 |
2.1.2.10 | aminomethyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
391993, 706478 |
2.1.4.1 | glycine amidinotransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
485975 |
2.3.1.12 | dihydrolipoyllysine-residue acetyltransferase |
mitochondrial inner membrane |
pyruvate dehydrogenase complex bound to inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
348927 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
486362, 486372 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
mitochondrial inner membrane |
cytoplasmic side of inner membrane |
GO:0005743 AmiGO QuickGO |
486381 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
mitochondrial inner membrane |
significant acyltransferase activity in inner membrane |
GO:0005743 AmiGO QuickGO |
486377 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
486541, 486544, 703967, 705753 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
CPT2 |
GO:0005743 AmiGO QuickGO |
659899 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
enzyme from outer and from inner membrane have different properties |
GO:0005743 AmiGO QuickGO |
486535, 486536 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
enzyme is present on both sides of the inner membrane, not on the outer membrane |
GO:0005743 AmiGO QuickGO |
486537, 486557 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
inner face of inner membrane |
GO:0005743 AmiGO QuickGO |
486552, 486553, 486555, 486558, 486561, 486566 |
2.3.1.21 | carnitine O-palmitoyltransferase |
mitochondrial inner membrane |
outer face of inner membrane |
GO:0005743 AmiGO QuickGO |
486523, 486538, 486553, 486555, 486556 |
2.3.1.37 | 5-aminolevulinate synthase |
mitochondrial inner membrane |
loosely bound |
GO:0005743 AmiGO QuickGO |
486818 |
2.3.1.B43 | protein-lysine desuccinylase (NAD+) |
mitochondrial inner membrane |
SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin |
GO:0005743 AmiGO QuickGO |
757175 |
2.3.3.16 | citrate synthase (unknown stereospecificity) |
mitochondrial inner membrane |
45% of CS II is bound to mitochondrial inner membrane and 2% of CS I |
GO:0005743 AmiGO QuickGO |
488068 |
2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
636998 |
2.6.1.7 | kynurenine-oxoglutarate transaminase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
-, 636623 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
642137 |
2.7.3.2 | creatine kinase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
737427 |
2.7.4.6 | nucleoside-diphosphate kinase |
mitochondrial inner membrane |
NDPK is attached to the outer side of the inner the membrane |
GO:0005743 AmiGO QuickGO |
672407 |
2.7.4.6 | nucleoside-diphosphate kinase |
mitochondrial inner membrane |
structural basis of NDPK-D/mitochondrial membrane interactions via binding of cardiolipin, overview |
GO:0005743 AmiGO QuickGO |
693134 |
2.7.4.6 | nucleoside-diphosphate kinase |
mitochondrial inner membrane |
structural basis of NDPK-D/mitochondrial membrane interactions, overview |
GO:0005743 AmiGO QuickGO |
693134 |
2.7.7.41 | phosphatidate cytidylyltransferase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
738000 |
2.8.2.B1 | APS sulfotransferase |
mitochondrial inner membrane |
periplasmic side |
GO:0005743 AmiGO QuickGO |
289091 |
3.1.3.43 | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase |
mitochondrial inner membrane |
inner surface of the inner membrane |
GO:0005743 AmiGO QuickGO |
94914 |
3.4.21.105 | rhomboid protease |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
659997 |
3.4.21.89 | Signal peptidase I |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
29808, 29815 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
653198, 681927, 711611, 712130, 712541, 712981, 713349, 718997 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
both subunit types span the membrane twice, integral, active at the matrix side of the inner membrane |
GO:0005743 AmiGO QuickGO |
649814 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
inner side, exposes catalytic sites to the mitochondrial matrix |
GO:0005743 AmiGO QuickGO |
650958 |
3.4.24.B18 | m-AAA protease |
mitochondrial inner membrane |
integral, active at the matrix side of the inner membrane |
GO:0005743 AmiGO QuickGO |
649814, 650372 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
653183, 681916, 692511, 694091 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
integral, a large domain is exposed to the intermembrane space |
GO:0005743 AmiGO QuickGO |
650958 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
integral, catalytic site facing the intermembrane space |
GO:0005743 AmiGO QuickGO |
649814 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
only subunit type Yme1p spans the membrane once, integral, catalytic site facing the inter membrane space |
GO:0005743 AmiGO QuickGO |
649814 |
3.4.24.B19 | i-AAA protease |
mitochondrial inner membrane |
outer surface of |
GO:0005743 AmiGO QuickGO |
653335 |
3.4.99.B2 | D-aspartyl endopeptidase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
667380, 695517 |
3.6.4.10 | non-chaperonin molecular chaperone ATPase |
mitochondrial inner membrane |
associated to on the matrix side |
GO:0005743 AmiGO QuickGO |
734351 |
3.6.5.5 | dynamin GTPase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
689227 |
3.6.5.5 | dynamin GTPase |
mitochondrial inner membrane |
Drp1 assembles into large complexes at future scission sites on the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
686382 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
4765, 4771, 4782, 4783, 4788 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
exclusively in the inner mitochondrial membrane |
GO:0005743 AmiGO QuickGO |
4779, 4791 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
external side of the inner membrane |
GO:0005743 AmiGO QuickGO |
4777 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
inner membrane |
GO:0005743 AmiGO QuickGO |
4776, 4783 |
4.1.1.65 | phosphatidylserine decarboxylase |
mitochondrial inner membrane |
membrane |
GO:0005743 AmiGO QuickGO |
4761, 4776 |
4.1.2.27 | sphinganine-1-phosphate aldolase |
mitochondrial inner membrane |
inner mitochondrial membrane possesses the highest activity |
GO:0005743 AmiGO QuickGO |
5112 |
4.1.2.27 | sphinganine-1-phosphate aldolase |
mitochondrial inner membrane |
membrane-bound |
GO:0005743 AmiGO QuickGO |
5112 |
4.2.1.17 | enoyl-CoA hydratase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
714222 |
4.4.1.17 | Holocytochrome-c synthase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
94056, 94057, 94058 |
4.4.1.17 | Holocytochrome-c synthase |
mitochondrial inner membrane |
integral membrane protein, facing cytoplasmic surface |
GO:0005743 AmiGO QuickGO |
94055 |
4.4.1.17 | Holocytochrome-c synthase |
mitochondrial inner membrane |
separation of mitochondrial inner and outer membrane on a sucrose gradient |
GO:0005743 AmiGO QuickGO |
665678 |
4.98.1.1 | protoporphyrin ferrochelatase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
729221, 729863 |
5.6.2.3 | DNA 5'-3' helicase |
mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
757877 |
6.3.2.17 | tetrahydrofolate synthase |
mitochondrial inner membrane |
the mitochondrial isoform is an integral membrane protein |
GO:0005743 AmiGO QuickGO |
744775 |