EC Number |
Recommended Name |
Localization |
GeneOntology No. |
Reference |
---|
4.2.2.7 | heparin lyase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
5975 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
infantile neuronal ceroid lipofuscinosis is a lysosomal storage disease |
GO:0005764 AmiGO QuickGO |
23914 |
3.2.1.31 | beta-glucuronidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
26856, 26862, 26864, 26866, 26867, 26872, 26873, 26876, 26877, 708528, 708531, 739626 |
3.4.22.24 | cathepsin T |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
30136, 30140, 665093 |
3.4.22.38 | cathepsin K |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 30362, 696041, 696617, 696631, 696654, 696664, 696697, 697011, 697012, 697066, 697257, 697375, 697619, 700688, 700689, 701180, 701297, 707334, 708260, 708423, 708450, 708689, 710231, 732741, 753618 |
3.4.11.3 | cystinyl aminopeptidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
35902, 35918 |
3.4.14.1 | dipeptidyl-peptidase I |
lysosome |
may by associated in a native matrix |
GO:0005764 AmiGO QuickGO |
36119 |
3.4.14.5 | dipeptidyl-peptidase IV |
lysosome |
membrane-bound form, 60%, and a soluble form, 40%. The main protein portion of the enzyme having the antigenic sites is located on the inside surface of lysosomes |
GO:0005764 AmiGO QuickGO |
36259 |
3.4.16.2 | lysosomal Pro-Xaa carboxypeptidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
36267, 665090, 683041, 706993 |
3.4.21.20 | cathepsin G |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
36500, 36501, 665912, 709353 |
3.1.1.3 | triacylglycerol lipase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
80838 |
3.1.1.3 | triacylglycerol lipase |
lysosome |
acid lipase |
GO:0005764 AmiGO QuickGO |
80849 |
3.1.1.32 | phospholipase A1 |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 649705, 666965, 94307, 94309, 94315, 94329 |
3.1.2.1 | acetyl-CoA hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
94471 |
3.1.3.5 | 5'-nucleotidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
95024, 95029 |
3.1.4.2 | glycerophosphocholine phosphodiesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
95148 |
3.4.14.2 | dipeptidyl-peptidase II |
lysosome |
compartmentalization of DPP II activity within lysosomal dense bodies that are concentrated primarily in the equatorial and sutural regions |
GO:0005764 AmiGO QuickGO |
95247 |
3.1.16.1 | spleen exonuclease |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
134141, 134143, 134146 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
enriched in porcine spleen |
GO:0005764 AmiGO QuickGO |
134288 |
4.6.1.18 | pancreatic ribonuclease |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
134535 |
3.1.3.2 | acid phosphatase |
lysosome |
membrane |
GO:0005764 AmiGO QuickGO |
134694, 134697, 134738 |
3.1.3.2 | acid phosphatase |
lysosome |
enzyme type B is localized to the organelles, presumably lysosomes, in both soluble form and membrane-bound form |
GO:0005764 AmiGO QuickGO |
134703 |
3.1.3.36 | phosphoinositide 5-phosphatase |
lysosome |
enzyme is associated with the lysosomal membrane |
GO:0005764 AmiGO QuickGO |
134820 |
3.1.3.4 | phosphatidate phosphatase |
lysosome |
only 3% of the total activity |
GO:0005764 AmiGO QuickGO |
134879 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135155, 135156, 135160, 135161, 135162, 135163, 135169, 135170, 135173, 651148, 652444, 653119, 664262, 690659, 692274, 714689, 730294, 751328, 751655 |
3.1.4.3 | phospholipase C |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 135301, 94309 |
3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135540, 135542, 135550, 135561, 135652, 652443, 654646, 680928, 691877, 694195, 694199, 707081, 707109, 707573, 708591, 709389, 709974 |
3.1.6.14 | N-acetylglucosamine-6-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135579 |
3.2.1.35 | hyaluronoglucosaminidase |
lysosome |
from liver |
GO:0005764 AmiGO QuickGO |
135648 |
3.1.6.4 | N-acetylgalactosamine-6-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135648, 135654, 666376, 680928, 694099 |
3.1.6.8 | cerebroside-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135511, 135666, 135667, 135668, 135669, 135670, 135671, 135672, 135674, 135676, 135677, 135679, 135680, 135681, 135682, 135683, 135684, 135685, 135686, 135687, 649289, 652443, 691881, 692081, 693260, 708615, 708623, 708662, 714958 |
3.2.1.25 | beta-mannosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
136027, 136032, 136035, 136045, 136050, 136056 |
3.2.1.25 | beta-mannosidase |
lysosome |
goat liver contains both an acid lysosomal beta-mannosidase, deficient in beta-mannosidosis, and a neutral nonlysosomal beta-mannosidase |
GO:0005764 AmiGO QuickGO |
136036 |
3.2.1.45 | glucosylceramidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
136448, 136449, 136453, 136459, 136460, 136461, 136470, 136474, 655772, 663458, 663619, 677311, 678095, 682510, 716414, 730162, 730656, 749459, 749981, 750910, 751287, 751573, 751834, 752045, 752178 |
3.2.1.53 | beta-N-acetylgalactosaminidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
136606 |
3.2.2.5 | NAD+ glycohydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
137074 |
3.4.22.42 | cathepsin O |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
137267 |
3.1.1.1 | carboxylesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
170986 |
3.2.1.22 | alpha-galactosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171218, 171240, 704691, 705734, 729607, 730674, 750344, 751953 |
3.2.1.96 | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase |
lysosome |
no evidence for a lysosomal enzyme form |
GO:0005764 AmiGO QuickGO |
171682 |
3.2.2.11 | beta-aspartyl-N-acetylglucosaminidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171768 |
3.2.1.51 | alpha-L-fucosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
208701, 208704, 208705, 208729, 208733, 208737, 739213, 750767 |
3.5.1.26 | N4-(beta-N-acetylglucosaminyl)-L-asparaginase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
209047, 209048, 209051, 209052, 209055, 209061, 209066, 668879, 681417, 712162, 712919, 735290, 753573, 753910, 755339 |
3.5.1.75 | urethanase |
lysosome |
highest activity, located mainly in the lysosomal fraction |
GO:0005764 AmiGO QuickGO |
209238 |
3.6.1.18 | FAD diphosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
209915 |
3.6.1.18 | FAD diphosphatase |
lysosome |
membrane |
GO:0005764 AmiGO QuickGO |
209923 |
3.6.1.2 | trimetaphosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
209932, 209935, 209941, 667198 |
3.6.1.2 | trimetaphosphatase |
lysosome |
basal elongated lysosome |
GO:0005764 AmiGO QuickGO |
209935 |
3.6.1.2 | trimetaphosphatase |
lysosome |
round and tubular structures |
GO:0005764 AmiGO QuickGO |
209940 |
3.6.1.26 | CDP-diacylglycerol diphosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
210005 |
5.6.1.3 | plus-end-directed kinesin ATPase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
210552 |
3.5.1.52 | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
288909 |
3.6.1.43 | dolichyldiphosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
289076 |
3.6.2.1 | adenylylsulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
289087, 289089, 289090 |
3.2.1.21 | beta-glucosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
326291, 326358, 664628, 664633 |
3.2.1.20 | alpha-glucosidase |
lysosome |
acid alpha-glucosidase I and II |
GO:0005764 AmiGO QuickGO |
393342 |
3.2.1.52 | beta-N-acetylhexosaminidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
393661, 393680, 393689, 393690, 393691, 393693, 393694, 393700, 393702, 393709, 654795, 679278, 707729, 751281 |
3.2.1.52 | beta-N-acetylhexosaminidase |
lysosome |
in healthy humans |
GO:0005764 AmiGO QuickGO |
393664 |
1.14.19.67 | salutaridine synthase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
393876 |
1.15.1.1 | superoxide dismutase |
lysosome |
Cu,Zn-SOD |
GO:0005764 AmiGO QuickGO |
438100 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
membrane bound, about one fourth of the activity |
GO:0005764 AmiGO QuickGO |
487501 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
integral membrane protein |
GO:0005764 AmiGO QuickGO |
487506, 487508 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
487507, 671200, 756105 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate |
GO:0005764 AmiGO QuickGO |
487503, 487504, 487508 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
489332 |
2.6.1.7 | kynurenine-oxoglutarate transaminase |
lysosome |
10% of liver total activity at pH 6.5 |
GO:0005764 AmiGO QuickGO |
-, 636611 |
2.5.1.2 | thiamine pyridinylase |
lysosome |
enzyme activity is mostly found in lysosomal fraction determined by differential centrifugation, sucrose and percoll gradients |
GO:0005764 AmiGO QuickGO |
636856 |
2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
636997 |
3.4.22.16 | cathepsin H |
lysosome |
biosynthesis in endoplasmic reticulum, proteolytic cleavage of proenzyme during translocation to lysosomes |
GO:0005764 AmiGO QuickGO |
638819 |
2.7.1.108 | dolichol kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
640393 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
lysosome |
membrane |
GO:0005764 AmiGO QuickGO |
641789 |
2.7.8.17 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
645368, 738667 |
3.1.2.2 | palmitoyl-CoA hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646190 |
3.1.2.20 | acyl-CoA hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646190 |
3.1.4.50 | glycosylphosphatidylinositol phospholipase D |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646479 |
3.1.6.18 | glucuronate-2-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646497, 646498 |
3.4.14.9 | tripeptidyl-peptidase I |
lysosome |
the conversion of the proenzyme into the mature form takes place in lysosomal compartment |
GO:0005764 AmiGO QuickGO |
647184 |
3.4.19.9 | folate gamma-glutamyl hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
647290, 647294, 647307, 647317, 683368, 683802 |
3.4.21.103 | physarolisin |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
647479 |
3.4.21.37 | leukocyte elastase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
647546, 647550, 696938 |
3.4.21.37 | leukocyte elastase |
lysosome |
lysosome-like granule |
GO:0005764 AmiGO QuickGO |
647548 |
3.4.22.15 | cathepsin L |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
647912, 647920, 647927, 647930, 669158, 678515, 678782, 680861, 681907, 707640, 710810, 711055, 711939, 712089, 712140, 713010, 713155, 717223, 752853, 753343, 753545, 753565, 753596, 755110 |
4.6.1.14 | glycosylphosphatidylinositol diacylglycerol-lyase |
lysosome |
predominantly acidic enzyme form |
GO:0005764 AmiGO QuickGO |
648768 |
3.1.6.13 | iduronate-2-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135566, 135567, 135568, 135569, 135570, 135571, 135572, 135573, 135574, 135575, 135576, 135577, 135578, 649290, 650331, 691079, 709973, 710212, 750121 |
3.1.1.53 | sialate O-acetylesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
651174, 715136, 94414 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
the glycoslated enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome |
GO:0005764 AmiGO QuickGO |
651450 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome |
GO:0005764 AmiGO QuickGO |
651451 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
PPT1 and PPT2 |
GO:0005764 AmiGO QuickGO |
652459 |
3.1.3.2 | acid phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 134700, 134719, 134729, 134750, 134758, 652665, 664547, 706063 |
3.2.1.1 | alpha-amylase |
lysosome |
isoenzymes alpha-I1 and alpha-I2 and muscle alpha-amylase |
GO:0005764 AmiGO QuickGO |
654030 |
3.5.1.26 | N4-(beta-N-acetylglucosaminyl)-L-asparaginase |
lysosome |
enzymic catalysis takes place in lysosomes |
GO:0005764 AmiGO QuickGO |
654537 |
3.2.1.18 | exo-alpha-sialidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171113, 171114, 171121, 171126, 171183, 654541, 678709, 681254, 701565, 702648, 704549, 729760, 730767 |
3.2.1.76 | L-iduronidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171552, 654856, 655246, 655683, 665552, 665938, 666018, 666374, 681942, 681947, 709198, 710324, 716239, 731075, 731638, 732511, 732821, 750300, 750326, 751839 |
3.5.1.23 | ceramidase |
lysosome |
CDase is distributed with late endosomes/lysosomes in hepatocytes |
GO:0005764 AmiGO QuickGO |
656010 |
3.2.1.18 | exo-alpha-sialidase |
lysosome |
major part |
GO:0005764 AmiGO QuickGO |
656030 |
1.4.3.2 | L-amino-acid oxidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
656435 |
3.2.1.24 | alpha-mannosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
136006, 136007, 656517, 656592, 656805, 664603, 665065, 729814, 750617, 751574 |
4.6.1.19 | ribonuclease T2 |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
656707 |
3.4.23.B1 | napsin |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
657686 |
3.2.1.127 | 1,6-alpha-L-fucosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
663840 |