EC Number |
Recommended Name |
Localization |
GeneOntology No. |
Reference |
---|
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
744236 |
1.14.19.67 | salutaridine synthase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
393876 |
1.15.1.1 | superoxide dismutase |
lysosome |
Cu,Zn-SOD |
GO:0005764 AmiGO QuickGO |
438100 |
1.4.3.2 | L-amino-acid oxidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
656435 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
711879 |
1.6.2.2 | cytochrome-b5 reductase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
724801 |
2.3.1.225 | protein S-acyltransferase |
lysosome |
enzyme class I |
GO:0005764 AmiGO QuickGO |
718835 |
2.3.1.43 | phosphatidylcholine-sterol O-acyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
736865 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
487507, 671200, 756105 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate |
GO:0005764 AmiGO QuickGO |
487503, 487504, 487508 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
integral membrane protein |
GO:0005764 AmiGO QuickGO |
487506, 487508 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
membrane bound, about one fourth of the activity |
GO:0005764 AmiGO QuickGO |
487501 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
lysosome |
the enzyme is synthesized as a catalytically inactive 77-kDa precursor that is transported to the lysosomes via an adaptor protein-mediated pathway that involves conserved tyrosine- and dileucine-based lysosomal targeting signals in its C-terminal cytoplasmic domain with a contribution from a dileucine-based signal in the N-terminal cytoplasmic loop. In the lysosome, the precursor is cleaved into a 29-kDa N-terminal alpha-chain and a 48-kDa C-terminal beta-chain, and assembled into active 440-kDa oligomers. The subunits are held together by disulfide bonds between at least two cysteine residues, Cys123 and Cys434, in the lysosomal luminal loops of the enzyme. |
GO:0005764 AmiGO QuickGO |
719889 |
2.3.2.23 | E2 ubiquitin-conjugating enzyme |
lysosome |
damaged |
GO:0005764 AmiGO QuickGO |
759124 |
2.4.1.228 | lactosylceramide 4-alpha-galactosyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
722567, 722691 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
489332 |
2.4.99.20 | 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
727868 |
2.5.1.2 | thiamine pyridinylase |
lysosome |
enzyme activity is mostly found in lysosomal fraction determined by differential centrifugation, sucrose and percoll gradients |
GO:0005764 AmiGO QuickGO |
636856 |
2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
636997 |
2.6.1.7 | kynurenine-oxoglutarate transaminase |
lysosome |
10% of liver total activity at pH 6.5 |
GO:0005764 AmiGO QuickGO |
-, 636611 |
2.7.1.108 | dolichol kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
640393 |
2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
761580 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
761780 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
lysosome |
membrane |
GO:0005764 AmiGO QuickGO |
641789 |
2.7.10.1 | receptor protein-tyrosine kinase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
738744 |
2.7.8.17 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
645368, 738667 |
3.1.1.1 | carboxylesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
170986 |
3.1.1.13 | sterol esterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
133830, 133840, 133841, 133853, 690334, 693513, 80838 |
3.1.1.3 | triacylglycerol lipase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
80838 |
3.1.1.3 | triacylglycerol lipase |
lysosome |
acid lipase |
GO:0005764 AmiGO QuickGO |
80849 |
3.1.1.32 | phospholipase A1 |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 649705, 666965, 94307, 94309, 94315, 94329 |
3.1.1.32 | phospholipase A1 |
lysosome |
whole-soluble lysosomal fraction |
GO:0005764 AmiGO QuickGO |
664591 |
3.1.1.4 | phospholipase A2 |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
133897, 133920, 681261, 730153 |
3.1.1.4 | phospholipase A2 |
lysosome |
and lysosomal-related organelles |
GO:0005764 AmiGO QuickGO |
751276 |
3.1.1.4 | phospholipase A2 |
lysosome |
lysosomal PLA2 isozyme |
GO:0005764 AmiGO QuickGO |
691654 |
3.1.1.53 | sialate O-acetylesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
651174, 715136, 94414 |
3.1.16.1 | spleen exonuclease |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
134141, 134143, 134146 |
3.1.2.1 | acetyl-CoA hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
94471 |
3.1.2.2 | palmitoyl-CoA hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646190 |
3.1.2.20 | acyl-CoA hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646190 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
23910, 23911, 23918, 650368, 650862, 651030, 653360, 653651, 692414, 716683, 751433, 751466, 751572, 751937 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome |
GO:0005764 AmiGO QuickGO |
651451 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
infantile neuronal ceroid lipofuscinosis is a lysosomal storage disease |
GO:0005764 AmiGO QuickGO |
23914 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
isoform PPT1 |
GO:0005764 AmiGO QuickGO |
750869 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
PPT1 and PPT2 |
GO:0005764 AmiGO QuickGO |
652459 |
3.1.2.22 | palmitoyl[protein] hydrolase |
lysosome |
the glycoslated enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome |
GO:0005764 AmiGO QuickGO |
651450 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 134302, 134305, 134308, 651415, 682740, 713781 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
and heterophagolysosome of macrophages and mononuclear cells, two bands with strong immunoreactivity appear at molecular masses of 30 and 23 kDa |
GO:0005764 AmiGO QuickGO |
730727 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
co-localization with Lamp-1 |
GO:0005764 AmiGO QuickGO |
679773 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
DNase IIbeta resides in the lysosomes of cortical fiber cells, close to the organelle-free zone |
GO:0005764 AmiGO QuickGO |
697574 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
during early differentiation |
GO:0005764 AmiGO QuickGO |
680266 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
enriched in porcine spleen |
GO:0005764 AmiGO QuickGO |
134288 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
post-translational processing of the DNase II to produce the alpha1, beta and alpha2 subunits occurs in the lysosome |
GO:0005764 AmiGO QuickGO |
697900 |
3.1.22.1 | deoxyribonuclease II |
lysosome |
the enzyme is localized in the lysosomal vacuolar system of both gill and digestive gland tissues |
GO:0005764 AmiGO QuickGO |
751444 |
3.1.3.19 | glycerol-2-phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
694049 |
3.1.3.19 | glycerol-2-phosphatase |
lysosome |
within |
GO:0005764 AmiGO QuickGO |
694049 |
3.1.3.2 | acid phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 134700, 134719, 134729, 134750, 134758, 652665, 664547, 706063 |
3.1.3.2 | acid phosphatase |
lysosome |
enzyme type B is localized to the organelles, presumably lysosomes, in both soluble form and membrane-bound form |
GO:0005764 AmiGO QuickGO |
134703 |
3.1.3.2 | acid phosphatase |
lysosome |
membrane |
GO:0005764 AmiGO QuickGO |
134694, 134697, 134738 |
3.1.3.21 | glycerol-1-phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
729762 |
3.1.3.36 | phosphoinositide 5-phosphatase |
lysosome |
enzyme is associated with the lysosomal membrane |
GO:0005764 AmiGO QuickGO |
134820 |
3.1.3.4 | phosphatidate phosphatase |
lysosome |
only 3% of the total activity |
GO:0005764 AmiGO QuickGO |
134879 |
3.1.3.5 | 5'-nucleotidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
95024, 95029 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
716970 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
lysosome |
membranes |
GO:0005764 AmiGO QuickGO |
665651 |
3.1.4.1 | phosphodiesterase I |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
208367, 208368, 713998 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135155, 135156, 135160, 135161, 135162, 135163, 135169, 135170, 135173, 651148, 652444, 653119, 664262, 690659, 692274, 714689, 730294, 751328, 751655 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
ASM is a secretory protein |
GO:0005764 AmiGO QuickGO |
678250 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
can rapidly move from lysosomes to cell surface upon stimulation by cytokines and other factors |
GO:0005764 AmiGO QuickGO |
666964 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
localizes to the lumen of lysosomes |
GO:0005764 AmiGO QuickGO |
691696 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
lysosomal aSMase, L-SMase |
GO:0005764 AmiGO QuickGO |
715641 |
3.1.4.12 | sphingomyelin phosphodiesterase |
lysosome |
lysosomal phosphodiesterase acid SMase |
GO:0005764 AmiGO QuickGO |
716445 |
3.1.4.2 | glycerophosphocholine phosphodiesterase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
95148 |
3.1.4.3 | phospholipase C |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 135301, 94309 |
3.1.4.4 | phospholipase D |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
707544 |
3.1.4.45 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
694897 |
3.1.4.50 | glycosylphosphatidylinositol phospholipase D |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646479 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135532, 693036, 707966, 709618, 709667, 709806, 730069 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
63-kDa single-chain precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes. Proteolytically processed arylsulfatase G fragments of 34-, 18-, and 10-kDa are found in lysosomal fractions and lost their membrane association. Lysosomal transport of arylsulfatase G in the liver is independent of mannose 6-phosphate, sortilin, and Limp2. Mutation of glycosylation site N497 abrogates transport to lysosomes, due to impaired mannose 6-phosphate modification |
GO:0005764 AmiGO QuickGO |
730056 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
inside membrane-bound cytoplasmic vesicles |
GO:0005764 AmiGO QuickGO |
681811 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
inside membrane-bound cytoplasmic vesicles distributed throughout the cell body |
GO:0005764 AmiGO QuickGO |
681811 |
3.1.6.1 | arylsulfatase (type I) |
lysosome |
protein carries mannose 6-phosphate, indicating lysosomal sorting |
GO:0005764 AmiGO QuickGO |
730022 |
3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135540, 135542, 135550, 135561, 135652, 652443, 654646, 680928, 691877, 694195, 694199, 707081, 707109, 707573, 708591, 709389, 709974 |
3.1.6.13 | iduronate-2-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135566, 135567, 135568, 135569, 135570, 135571, 135572, 135573, 135574, 135575, 135576, 135577, 135578, 649290, 650331, 691079, 709973, 710212, 750121 |
3.1.6.14 | N-acetylglucosamine-6-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135579 |
3.1.6.18 | glucuronate-2-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
646497, 646498 |
3.1.6.4 | N-acetylgalactosamine-6-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135648, 135654, 666376, 680928, 694099 |
3.1.6.8 | cerebroside-sulfatase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
135511, 135666, 135667, 135668, 135669, 135670, 135671, 135672, 135674, 135676, 135677, 135679, 135680, 135681, 135682, 135683, 135684, 135685, 135686, 135687, 649289, 652443, 691881, 692081, 693260, 708615, 708623, 708662, 714958 |
3.10.1.1 | N-sulfoglucosamine sulfohydrolase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
288761, 288767, 687034, 689003, 689776, 718540 |
3.2.1.1 | alpha-amylase |
lysosome |
isoenzymes alpha-I1 and alpha-I2 and muscle alpha-amylase |
GO:0005764 AmiGO QuickGO |
654030 |
3.2.1.106 | mannosyl-oligosaccharide glucosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
694198, 700317 |
3.2.1.113 | mannosyl-oligosaccharide 1,2-alpha-mannosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
-, 695429 |
3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
664603 |
3.2.1.127 | 1,6-alpha-L-fucosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
663840 |
3.2.1.14 | chitinase |
lysosome |
secretory |
GO:0005764 AmiGO QuickGO |
664449 |
3.2.1.163 | 1,6-alpha-D-mannosidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171768, 673892, 674494, 706628 |
3.2.1.166 | heparanase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
715536, 753404, 754873 |
3.2.1.166 | heparanase |
lysosome |
heparanase-1 is mostly an intracellular, lysosomal enzyme. Only in cases where the receptor-system is absent or defective, the enzyme accumulates extracellularly. The enzyme is stored within the acidic compartments in a stable form. Active enzyme can be secreted from intracellular compartments in response to a proper and effective stimulus |
GO:0005764 AmiGO QuickGO |
693320 |
3.2.1.167 | baicalin-beta-D-glucuronidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
712143 |
3.2.1.18 | exo-alpha-sialidase |
lysosome |
- |
GO:0005764 AmiGO QuickGO |
171113, 171114, 171121, 171126, 171183, 654541, 678709, 681254, 701565, 702648, 704549, 729760, 730767 |