EC Number   |
Localization |
GeneOntology No.  |
Reference |
|---|
   2.7.11.16 | cell membrane |
association of GRK6 with the cell membrane is mediated in part by the palmitoylation of cysteine residues that lie in a C-terminal region |
- |
674574 |
| 2.7.11.16 | more |
chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression |
- |
689792 |
| 2.7.11.16 | more |
GRK4, GRK5, and GRK6 lack the G protein betagamma-subunit binding domain but use direct PIP2 binding and/or covalent lipid modification with palmitate to reside primarily at the plasma membrane |
- |
671352 |
| 2.7.11.16 | nucleus |
- |
GO:0005634 AmiGO QuickGO |
689792, 738658, 739464, 760266 |
| 2.7.11.16 | nucleus |
GRK2 is enriched more than 4fold in the nucleus compared to cytoplasm |
GO:0005634 AmiGO QuickGO |
726308 |
| 2.7.11.16 | nucleus |
GRK5 |
GO:0005634 AmiGO QuickGO |
672408 |
| 2.7.11.16 | nucleus |
phosphorylated GRK5 is enriched more than 4fold in the nucleus compared to cytoplasm |
GO:0005634 AmiGO QuickGO |
726308 |
| 2.7.11.16 | cytoplasm |
- |
GO:0005737 AmiGO QuickGO |
671352, 726308 |
| 2.7.11.16 | cytoplasm |
the GRK5 subcellular distribution in the human striatal neurons is altered by its phosphorylation: phosphorylated GRK5 is found in plasma membrane and cytosolic fractions |
GO:0005737 AmiGO QuickGO |
726308 |
| 2.7.11.16 | centrosome |
GRK5 co-localizes with gamma-tubulin, centrin, and pericentrin in centrosomes. The centrosomal localization of GRK5 is observed predominantly at interphase and although its localization is not dependent on microtubules, it can mediate microtubule nucleation of centrosome |
GO:0005813 AmiGO QuickGO |
725509 |
