EC Number |
Inhibitors |
Structure |
---|
4.2.1.74 | iodoacetamide |
5 mM, 16% inhibition |
|
4.2.1.74 | more |
long chain enoyl-CoA hydratase of pig heart is not inhibited by acetoacetyl-CoA |
|
4.2.1.74 | more |
no inhibition by acetoacetyl-CoA |
|
4.2.1.74 | N-Methylmaleimide |
- |
|
4.2.1.74 | N-Methylmaleimide |
1 mM, 69% inhibition, substrate: trans-octenoyl-CoA |
|
4.2.1.74 | oct-2-yn-4-enoyl-CoA |
irreversible inhibitor of 2-enoyl-CoA hydratase 2 (ECH2), covalent modification shown by peptide mass spectrometry, hydratase reaction of 2-enoyl-CoA hydratase 2 requires two protic residues, suggesting that the reaction follows a process of acid-base catalysis, only a weak reversible inhibitor of 2-enoyl-CoA hydratase 1 (ECH1), inhibitor concentrations up to 25 microM, inactivates also the beta-subunit of the mitochondrial trifunctional enzyme (MTP) and medium-chain acyl-CoA dehydrogenase (MCAD) |
|
4.2.1.74 | p-chloromercuribenzoate |
- |
|
4.2.1.74 | p-chloromercuribenzoate |
1 mM, complete inhibition |
|