EC Number   |
Inhibitors |
Structure |
|---|
    4.2.1.17 | (3S)-hydroxybutanoyl-CoA |
competitive |
   |
| 4.2.1.17 | (3S)-hydroxyhexadecanoyl-CoA |
competitive, 50% inhibition at 0.00075 mM, 90% inhibition by 0.004 mM |
|
| 4.2.1.17 | (R)-methylenecyclopropylformyl-CoA |
methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1 |
|
| 4.2.1.17 | (S)-methylenecyclopropylformyl-CoA |
methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1 |
|
| 4.2.1.17 | 3-ketohexadecanoyl-CoA |
0.008 mM, 40% inhibition |
|
| 4.2.1.17 | 3-octynoyl-CoA |
irreversibly inactivates only enoyl-CoA hydratase 2, the catalytic residue Glu47 is covalently labeled by the inhibitor |
|
| 4.2.1.17 | acetoacetyl-CoA |
enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme |
|
| 4.2.1.17 | acetoacetyl-CoA |
- |
|
| 4.2.1.17 | acetoacetyl-CoA |
competitive inhibitor, binding structure, overview |
|
| 4.2.1.17 | acetyl-CoA |
0.1 mM, 70% inhibition |
|
