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EC Number
Inhibitors
Commentary
Structure
4.1.1.32
(Z)-Phosphoenol-3-bromopyruvate
linear competitive
4.1.1.32
1-allyl-3-butyl-8-methylxanthine
weak, competitive inhibitor with respect to GTP, IC50: 0.225 mM in the decarboxylation direction, modifications at N-1 and C-8 improve the inhibitory activity by more than 100fold
4.1.1.32
2,3-Butanedione
-
4.1.1.32
2-oxobutanoate
weak
4.1.1.32
2-oxoglutarate
above 5.0 mM, weak
4.1.1.32
2-oxoglutarate
competitive with respect to both oxaloacetate and phosphoenolpyruvate
4.1.1.32
2-oxoglutarate
-
4.1.1.32
2-oxoglutarate
in both directions, competitive with respect to oxaloacetate or phosphoenolpyruvate, noncompetitive with respect GTP or Mn2+
4.1.1.32
2-oxoglutarate
weak inhibition
4.1.1.32
2-Phosphoglycolate
-
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