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Results 1 - 5 of 5
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EC Number Inhibitors Commentary Structure
Show all pathways known for 3.5.4.19Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.195,5'-dithiobis(2-nitrobenzoic acid) compromises the Zn2+ binding properties of the protein inducing loss of up to 90% of the metal. The enzyme is protected from inactivation by inclusion of the substrate N1-(5'-phosphoribosyl)adenosine 5'-monophosphate, while Mg2+, a metal required for catalytic activity, enhanced the rate of inactivation Go to the Ligand Summary Page
Show all pathways known for 3.5.4.19Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.19EDTA reversible inhibition Go to the Ligand Summary Page
Show all pathways known for 3.5.4.19Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.19methyl methane thiosulfonate compromises the Zn2+ binding properties of the protein inducing loss of up to 90% of the metal Go to the Ligand Summary Page
Show all pathways known for 3.5.4.19Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.19more ZINC04880153 can be considered as one of the potential lead molecule against HisI drug target in Brucella melitensis. Low binding energy (-9.1kcal/mol) with a molecular weight of 228.191 g/mol. It has 2 H-bond donors and 7 H-bond acceptors. The movement of ZINC04880153 in the binding pockets of HisI shows stability and compact structure with respect to the initial computational model of HisI Go to the Ligand Summary Page
Show all pathways known for 3.5.4.19Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.19Zn2+ exogenous Zn2+ Go to the Ligand Summary Page
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