EC Number   |
Inhibitors |
Structure |
|---|
   3.5.3.15 | (3R)-3-[2-[4-(2-carbamimidamidoethyl)-1H-1,2,3-triazol-1-yl]acetamido]-3-(4-fluorophenyl)propanoic acid |
1,2,3-triazole peptidomimetic-based compound, 39% inhibition at 1 microM, 99% inhibition at 10 microM |
   |
| 3.5.3.15 | (3S)-3-[2-[4-(2-carbamimidamidoethyl)-1H-1,2,3-triazol-1-yl]acetamido]-3-phenylpropanoic acid |
1,2,3-triazole peptidomimetic-based compound, 26% inhibition at 1 microM, 69% inhibition at 10 microM |
|
| 3.5.3.15 | 1-(2-{4-[(aminooxy)sulfinyl]phenyl}ethyl)guanidine hydrochloride |
5% inhibition at 0.01 mM |
|
| 3.5.3.15 | 1-[3-(1H-imidazol-4-yl)propyl]-3-{2-[(4-phenyl-1,2,5-oxadiazol-3-yl)oxy]ethyl}guanidine hydrochloride |
34% inhibition at 0.01 mM |
|
| 3.5.3.15 | 1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-chloroethaniminium |
- |
|
| 3.5.3.15 | 1-[[4-(benzoylamino)-5-(ethylamino)-5-oxopentyl]amino]-2-fluoroethaniminium |
- |
|
| 3.5.3.15 | 1-[[6-amino-5-(benzoylamino)-6-oxohexyl]amino]-2-chloroethaniminium |
potent, irreversible and specific PAD3 inhibitor |
|
| 3.5.3.15 | 1-[[6-amino-5-(benzoylamino)-6-oxohexyl]amino]-2-fluoroethaniminium |
potent, irreversible and specific PAD3 inhibitor |
|
| 3.5.3.15 | 2-({(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-chloroethanimidoyl)amino]butyl}carbamoyl)benzoic acid |
- |
|
| 3.5.3.15 | 2-({(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-fluoroethanimidoyl)amino]butyl}carbamoyl)benzoic acid |
- |
|
