EC Number   |
Inhibitors |
Structure |
|---|
   3.4.21.43 | C1 inhibitor |
blocks the the classical pathway |
 |
| 3.4.21.43 | C4b-binding protein |
regulates assembly and decay of the classical pathway C3/C5 convertase 4times lower than the lectin pathway convertase |
|
| 3.4.21.43 | C4BP |
effectively inhibits both C3 and C5 conversion |
|
| 3.4.21.43 | C4d antibody |
blocks the the classical pathway |
|
| 3.4.21.43 | CN- |
inhibits the aggregation of C4b and C2a and the activity of the active enzyme |
  |
| 3.4.21.43 | complement receptor of immunoglobulin family |
inhibits C5 conversion specifically |
|
| 3.4.21.43 | complement receptor type 1-related protein y |
i.e. Crry, a mouse-specific complement inhibitor, expressed in astrocytes, microglia, and neurons of murine brain, in vivo and in vitro inhibition of C3 convertase, overview |
|
| 3.4.21.43 | Cp40 |
the inhibitor shows potent inhibition of C3 conversion |
|
| 3.4.21.43 | diisopropyl fluorophosphate |
- |
|
| 3.4.21.43 | eculizumab |
potently inhibits C5 conversion but leaves C3 conversion unaffected |
|
