EC Number |
Inhibitors |
Structure |
---|
3.1.21.7 | (NH4)2SO4 |
50% inhibition at 25 mM, inhibition of formation of acid-soluble products |
|
3.1.21.7 | Ag2+ |
50% inhibition at 0.01 mM |
|
3.1.21.7 | ATP |
1 mM ATP almost completely inhibits hEndoV activity. hEndoV cleavage is inhibited by normal intracellular ATP concentrations. The ATP stores inside a cell do not overlay stress granules and it is suggest that hEndoV is redistributed to stress granules as a strategy to create a local environment low in ATP to permit hEndoV activity |
|
3.1.21.7 | Ca2+ |
- |
|
3.1.21.7 | Co2+ |
- |
|
3.1.21.7 | Cu2+ |
50% inhibition at 0.025 mM |
|
3.1.21.7 | Fe3+ |
strong inhibition |
|
3.1.21.7 | Hg2+ |
50% inhibition at 0.0006 mM, inhibition of both DNA glycosylase and apurinic nicking activities, binding capability not reduced |
|
3.1.21.7 | KCl |
above 100 mM, strong inhibition |
|
3.1.21.7 | Mn2+ |
at pH 8.5, a Mn2+ concentration of 2.5 mM and higher inhibits activity |
|