EC Number   |
Inhibitors |
Structure |
|---|
   3.1.13.2 | (10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)acetic acid |
- |
   |
| 3.1.13.2 | (2E)-2-[(4-chlorophenyl)hydrazono]propanoic acid |
4-chlorophenylhydrazone of pyruvic acid, shows poor inhibitory activity against HIV-1 RNase H because of the storage of one or two carboxylic acid moieties |
|
| 3.1.13.2 | (2Z)-2-hydroxy-4-oxopent-2-enoic acid |
- |
|
| 3.1.13.2 | (E)-3,4-dihydroxy-N'-((2-methoxynaphthalen-1-yl)methylene)benzohydrazide |
i.e. DHBNH, highly specific, noncompetitive, binding site analysis, the inhibitor binds near both the polymerase active site and the non-nucleoside reverse transcriptase inhibitor binding pocket, it specifically interacts with conserved residues Asp186 and Trp229 and has substantial interactions with the backbones of several less well-conserved residues, overview, substituted inhibitor derivatives, that interact with the nucleoside analog RT inhibitor-binding pocket, inhibit both the polymerase and RNH activities of reverse transcriptase, DHBNH interacts with other residues, including Val108, Leu187, Tyr188, Lys223, Phe227, and Leu228 |
|
| 3.1.13.2 | 1,3,4,5-tetragalloylapiitol |
isolated from the aqueous extract of leaves of the plant Hylodendron gabunensis |
|
| 3.1.13.2 | 1,3,4,5-tetragalloylapiitol |
extracted from the plant Hylodendron gabunense, also inhibitory effective against HIV-2 RNase H |
|
| 3.1.13.2 | 1,4-Naphthoquinone |
- |
|
| 3.1.13.2 | 1,6-dihydroxy-4-methyl-5-(N-phenoxyethanimidoyl)pyridin-2(1H)-one |
- |
|
| 3.1.13.2 | 1,6-dihydroxy-4-methyl-5-[N-[(4-methylphenyl)methoxy]ethanimidoyl]pyridin-2(1H)-one |
- |
|
| 3.1.13.2 | 1,6-dihydroxy-5-[N-[(2-methoxyphenyl)methoxy]ethanimidoyl]-4-methylpyridin-2(1H)-one |
- |
|
