EC Number   |
Inhibitors |
Structure |
|---|
    3.1.1.17 | ascorbate/Cu2+ |
oxidative system ascorbate/Cu2+ is the most potent in inactivating the lactonase activity of purified PON1, 0.5 mM/0.001 mM: up to 100% inhibition, 0.1 mM/0.001 mM: 90% inhibition, 95%-100% inhibition. Oleic acid prevents the ascorbate/Cu2+-induced inactivation |
   |
| 3.1.1.17 | ascorbate/Fe2+ |
0.5 mM/0.002 mM: 20% inhibiiton |
|
| 3.1.1.17 | Cu2+ |
0.001 mM, 30% inhibition |
|
| 3.1.1.17 | Diazotetrazole |
- |
|
| 3.1.1.17 | EDTA |
highly sensitive to EDTA, the lost activity can be restored to the original level by the addition of divalent cations of the order Ca2+ = Mg2+ > Zn2+ > Fe2+ = Co2+, Mn2+, Ni2+, Cu2+ > Mo2+ |
|
| 3.1.1.17 | EDTA |
strong inhibition |
|
| 3.1.1.17 | EDTA |
partially sensitive to EDTA |
|
| 3.1.1.17 | EDTA |
Mg2+ or Ca2+ protects against inactivation |
|
| 3.1.1.17 | EGTA |
highly sensisitve to EGTA, the lost activity can be restored to the original level by the addition of divalent cations of the order Ca2+ = Mg2+ > Zn2+ > Fe2+ = Co2+, Mn2+, Ni2+, Cu2+ > Mo2+ |
|
| 3.1.1.17 | ethanol |
10 mM, 20% inhibition |
|
