EC Number |
Inhibitors |
Structure |
---|
2.8.1.7 | 4-chloromercuribenzoate |
preincubation dramatically inhibits enzyme activity |
|
2.8.1.7 | D-cycloserine |
inhibitor of PLP-dependent enzymes, inhibits CPSIT_0959 protein catalytic activity |
|
2.8.1.7 | dithiothreitol |
activity is strongly dependent on the presence of dithiothreitol, with activity increasing up to 46% when the reductant is present in the reaction mixture. Concentrations higher than 5 mM cause an inhibitory effect |
|
2.8.1.7 | Fe2+ |
the low desulfurase activity is caused by the modification of IscS rather than by the formation of FeS in the solution |
|
2.8.1.7 | interferon-gamma |
downregulation of cysteine desulfurase and its protein partner IscU at both mRNA and protein level by stimulation of macrophages with interferon-gamma; the cysteine desulfurase Nfs1 and its scaffold protein partner IscU are down-regulated at both mRNA and protein levels when murine macrophages are physiologically stimulated with interferon-gamma |
|
2.8.1.7 | iodoacetamide |
preincubation dramatically inhibits enzyme activity |
|
2.8.1.7 | K2TeO3 |
mutant strains csdA::Kn, csdB::Kn, ascS::Kn |
|
2.8.1.7 | L-Allylglycine |
irreversible inactivation |
|
2.8.1.7 | L-cysteine |
above 0.5 mM |
|
2.8.1.7 | L-selenocysteine |
inhibits desulfuration of L-cysteine |
|