EC Number   |
Inhibitors |
Structure |
|---|
    2.6.1.99 | (2S)-2-(aminooxy)-3-(naphthalen-2-yl)propanoic acid |
competitive. Arabidopsis thaliana seedlings treated with the compound show typical auxin-deficient phenotypes, which are reversed by exogenous indole-3-acetic acid |
   |
| 2.6.1.99 | L-alpha-aminooxy-phenylpropionic acid |
target compound for inhibitor synthesis |
|
| 2.6.1.99 | L-kynurenine |
an alternate substrate, competitively inhibits TAA1/TAR activity, and Kyn treatment mimicks the loss of TAA1/TAR functions. L-kynurenine application represses activity and nuclear accumulation of the EIN3 transcription factor in roots. L-kynurenine effectively and selectively binds to the substrate pocket of TAA1/TAR proteins but not to those of other families of aminotransferases, computational docking and molecular modeling, overview |
|
| 2.6.1.99 | L-kynurenine |
a potent inhibitor of in vivo TAA1/TAR activity |
|
| 2.6.1.99 | more |
synthesis of inhibitors based on L-alpha-aminooxy-phenylpropionic acid. The aminooxy and carboxy groups of the compound are essential for inhibition of TAA1 in vitro. Inhibitory activity of the compounds is correlated with their binding energy with TAA1. The active compounds reduce the endogenous indole-3-acetic acid content upon application to Arabidopsis thaiana seedlings |
|
