EC Number |
Inhibitors |
Structure |
---|
2.5.1.16 | 1,3-diaminopropane |
34% inhibition |
|
2.5.1.16 | 1,3-diaminopropane |
96% inhibition at 0.01 mM and 100% inhibition at 0.1 mM |
|
2.5.1.16 | 1,5-Diaminopentane |
weak, competitive |
|
2.5.1.16 | 1,6-diaminohexane |
23% inhibition |
|
2.5.1.16 | 1-Aminooxy-3-aminopropane |
brain enzyme, specific, no inhibition of spermine synthase, reversible, competitive with 1,4-diaminobutane |
|
2.5.1.16 | 1-Aminooxy-3-aminopropane |
poor inhibition |
|
2.5.1.16 | 1H-benzimidazol-5-yl(4-[(2Z)-3-phenylprop-2-en-1-yl]piperazin-1-yl)methanone |
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site and partially competes with binding of methylthioadenosine |
|
2.5.1.16 | 2-mercaptoethylamine |
competitive with 1,4-diaminobutane, reversible, its removal restores the enzyme activity, the amino group is necessary to inhibit the enzyme |
|
2.5.1.16 | 2-mercaptoethylamine |
poor inhibition |
|
2.5.1.16 | 2-phenyl-1,2-thiazol-3(2H)-one |
- |
|