EC Number |
Inhibitors |
Structure |
---|
2.3.1.135 | 13-demethyl-13,14-dihydro-all-trans-retinyl trifluoroacetate |
competitive with respect to dipalmitoylphosphocholine, uncompetitive with respect to all-trans-retinol; reversible inhibitor |
|
2.3.1.135 | all-trans-retinyl-alpha-bromoacetate |
irreversible inhibition |
|
2.3.1.135 | all-trans-retinyl-alpha-bromoacetate |
- |
|
2.3.1.135 | all-trans-retinylbromoacetate |
- |
|
2.3.1.135 | Apo-cellular-retinol-binding protein |
- |
|
2.3.1.135 | apo-CRBP-I |
i.e. apo-[cellular retinol-binding protein I], no inhibition by apo-CRBP-III |
|
2.3.1.135 | fenretinide |
used clinically to presumably lower blood retinol-binding protein levels and thus decrease circulating retinol, targets the functional coupling of STRA6 and LRAT to increase cellular vitamin A uptake in peripheral tissues |
|
2.3.1.135 | more |
inactivated by trivalent arsenicals |
|
2.3.1.135 | more |
1% dimethylsulfoxide does not inhibit LRAT activity |
|
2.3.1.135 | more |
1-acyl-lysophosphatidylcholine does not inhibit LRAT up to 0.020 mM; product inhibition by retinyl ester can be ruled out |
|