EC Number   |
Inhibitors |
Structure |
|---|
   2.1.1.8 | (5'-amino-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-[4-(3-piperidin-1-yl-propoxy)-phenyl]-methanone |
50% inhibition at 0.0020 mM, simultaneously a highly potent H3 receptor ligand |
   |
| 2.1.1.8 | (5'-nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-[4-(3-piperidin-1-yl-propoxy)-phenyl]-methanone |
50% inhibition at 0.0015 mM, simultaneously a highly potent H3 receptor ligand |
|
| 2.1.1.8 | (5-nitro-pyridin-2-yl)-[4-(3-piperidin-1-yl-propoxy)-benzyl]-amine |
50% inhibition at 0.0042 mM, simultaneously a highly potent H3 receptor ligand |
|
| 2.1.1.8 | (5-nitro-pyridin-2-yl)-{2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-amine |
50% inhibition at 0.0028 mM, simultaneously a highly potent H3 receptor ligand |
|
| 2.1.1.8 | (5-nitro-pyridin-2-yl)-{3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-amine |
50% inhibition at 0.0017 mM, simultaneously a highly potent H3 receptor ligand |
|
| 2.1.1.8 | (5-nitro-pyridin-2-yl)-{4-[4-(3-piperidin-1-yl-propoxy)-phenyl]-butyl}-amine |
50% inhibition at 0.0017 mM, simultaneously a highly potent H3 receptor ligand |
|
| 2.1.1.8 | (R)-chloroquine |
50% inhibition at 0.018 mM, liver enzyme, 50% inhibition at 0.0022 mM, brain enzyme |
|
| 2.1.1.8 | (S)-chloroquine |
50% inhibition at 0.005 mM, liver enzyme, 50% inhibition at 0.007 mM, brain enzyme |
|
| 2.1.1.8 | 1-(3-(4-(3,4-dihydro-2H-pyrrol-5-yl)phenoxy)propyl)piperidine |
50% inhibition at 0.0090 mM, simultaneously a highly potent H3 receptor ligand |
|
| 2.1.1.8 | 1-Methylhistamine |
strong |
|
