EC Number   |
Inhibitors |
Structure |
|---|
    1.5.1.3 | (-)-epicatechin |
- |
   |
| 1.5.1.3 | (-)-epicatechin gallate |
competitive to 7,8-dihydrofolate, formation of a slow dissociation ternary complex by the reaction of NADPH with the enzyme-inhibitor complex. Ionization state of E30 is critical for inhibitory activity |
|
| 1.5.1.3 | (-)-epicatechin gallate |
- |
|
| 1.5.1.3 | (-)-epigallocatechin gallate |
competitive to 7,8-dihydrofolate, formation of a slow dissociation ternary complex by the reaction of NADPH with the enzyme-inhibitor complex. Ionization state of E30 is critical for inhibitory activity |
|
| 1.5.1.3 | (1E)-1-[4-[(3,5-dichloropyridin-4-yl)oxy]phenyl]ethanone thiosemicarbazone |
- |
|
| 1.5.1.3 | (2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate |
- |
|
| 1.5.1.3 | (2,5-dimethyl-1,4-phenylene)bis(methylene) bis(N-[amino(imino)methyl](imidothiocarbamate)) |
50% inhibition at 0.000075 mM |
|
| 1.5.1.3 | (2-(4-((2,4-diaminopyrimidine-5-yl)methyl)-2,6-dimethoxyphenoxy)-2-oxoethyl)glutamic acid |
16fold selectivity for Leishmania major enzyme over human enzyme |
|
| 1.5.1.3 | (2-(4-((2,4-diaminopyrimidine-5-yl)methyl)-2,6-dimethoxyphenoxy)-2-oxoethyl)leucine |
84fold selectivity for Leishmania major enzyme over human enzyme |
|
| 1.5.1.3 | (2-(4-((2,4-diaminopyrimidine-5-yl)methyl)-2,6-dimethoxyphenoxy)-2-oxoethyl)phenylalanine |
87fold selectivity for Leishmania major enzyme over human enzyme |
|
