EC Number |
Inhibitors |
Structure |
---|
1.2.1.104 | 1-(4-bromophenyl)ethanone O-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)oxime |
thiamine diphosphate analog, at 0.1 mM 33% inhibition against Gibberlla zeae |
|
1.2.1.104 | 1-(4-chlorophenyl)ethanone O-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)oxime |
thiamine diphosphate analog, at 0.1 mM 35% inhibition against Gibberlla zeae |
|
1.2.1.104 | 1-(4-nitrophenyl)ethanone O-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)oxime |
thiamine diphosphate analog, at 0.1 mM 50% inhibition against Gibberlla zeae |
|
1.2.1.104 | 1-[3-[4-(1,3,2-dithiarsinan-2-yl)anilino]-3-oxopropyl]-4-[(E)-2-(1H-indol-3-yl)ethenyl]pyridin-1-ium |
i.e. PDT-PAO-16, organic arsenal inhibitor, mainly accumulates in mitochondria within hours and suppresses the activity of the pyruvate dehydrogenase complex resulting in the inhibition of ATP synthesis and thermogenesis disorder. The suppression of respiratory chain complex I and IV accelerates the mitochondrial dysfunction leading to caspase family-dependent apoptosis. In vivo, the acute promyelocytic leukemia is greatly alleviated in the PDT-PAO-F16 treated group in an acute promyelocytic leukemia mice model |
|
1.2.1.104 | 2,3-Butanedione |
10 mM, biphasic kinetic, complete inactivation after 20 min |
|
1.2.1.104 | 2-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-1H-isoindole-1,3(2H)-dione |
potent algaecidal activity against Synechocystis sp. PCC 6803 |
|
1.2.1.104 | 2-p-Toluidinonaphthalene-6-sulfonate |
- |
|
1.2.1.104 | 3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-5-chloroquinazolin-4(3H)-one |
- |
|
1.2.1.104 | 3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-6-bromoquinazolin-4(3H)-one |
- |
|
1.2.1.104 | 3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-6-bromoquinazolin-4(3H)-one |
potent algaecidal activity against Synechocystis sp. PCC 6803 |
|