EC Number   |
Inhibitors |
Structure |
|---|
    1.17.4.1 | (-)-epicatechin |
interacts with the R2 protein, leading to a loss of the tyrosyl radical EPR signal. Proliferation of cells exposed to (-)-epicatechin is downregulated, and deoxyribonucleotide levels are significantly diminished |
   |
| 1.17.4.1 | (2E)-2-(anthracen-9-ylmethylidene)-N-hydroxyhydrazinecarboximidamide |
i.e. ABNM-13, application leads to significant alterations of deoxyribonucleoside triphosphate pool balance and a highly significant decrease of incorporation of radiolabeled cytidine into DNA of HL-60 cells. Diminished ribonucleotide reductase activity causes replication stress which is consistent with activation of Chk1 and Chk2, resulting in downregulation/degradation of Cdc25A. Cdc25B is upregulated, leading to dephosphorylation and activation of Cdk1. The combined disregulation of Cdc25A and Cdc25B is the most likely cause for ABNM-13 induced S-phase arrest |
|
| 1.17.4.1 | (E)-2'-fluoromethylene-2'-deoxycytidine-5-diphosphate |
i.e. N3dNDP, inhibitor forming a furanone intermediate. Modeling of enzyme-inhibitor complex |
|
| 1.17.4.1 | 1,10-phenanthroline |
- |
|
| 1.17.4.1 | 1,10-phenanthroline |
0.2 mM, 50% inhibition |
|
| 1.17.4.1 | 1-Formylisoquinoline thiosemicarbazone |
0.0006 mM, 81% inhibition, 0.1 mM desferal reverses inhibition |
|
| 1.17.4.1 | 1-methyl-1-hydroxyurea |
10 mM, 55% inhibition |
|
| 1.17.4.1 | 2',3'-dideoxy-ATP |
less potent inhibitor than dATP, 0.1 mM, 50% inhibition of CDP reduction |
|
| 1.17.4.1 | 2'-azido-2'-deoxynucleotides |
- |
|
| 1.17.4.1 | 2'-chloro-2'-deoxycytidine 5'-diphosphate |
- |
|
