EC Number   |
Inhibitors |
Structure |
|---|
   1.14.14.47 | 3-bromo-7-nitroindazole |
- |
   |
| 1.14.14.47 | 3-[2,4-di(6-amino-4-methylpyridin-2-yl)ethyl]benzonitrile |
inhibitor binds to heme propionate A through a bifurcated H-bond and a pi-pi stacking interaction between the conserved Tyr and aminopyridine group |
|
| 1.14.14.47 | 4-methylquinolin-2-amine |
among the most potent aminoquinoline inhibitors tested, KS value 0.00080 mM |
|
| 1.14.14.47 | 6,6'-[(5-amino-1,3-phenylene)di(ethane-2,1-diyl)]bis(4-methylpyridin-2-amine) |
compound interacts with the active site Glu243 and heme propionate D through a series of hydrogen bonds between the aminopyridine functional groups. Comparison with inhibition of mammalian NOS isoforms |
|
| 1.14.14.47 | 6,6'-[[(2S,3S)-2-aminobutane-1,3-diyl]bis(oxymethanediyl)]bis(4-methylpyridin-2-amine) |
compound impedes the growth of Bacillus subtilis under oxidative stress an is able to displace the tetrahydrobiopterin cofactor in the Bacillus subtilis enzyme but not in the mouse enzyme |
|
| 1.14.14.47 | 6,6'-[[5-(aminomethyl)-1,3-phenylene]di(ethane-2,1-diyl)]bis(4-methylpyridin-2-amine) |
compound interacts with the active site Glu243 and heme propionate D through a series of hydrogen bonds between the aminopyridine functional groups. Comparison with inhibition of mammalian NOS isoforms |
|
| 1.14.14.47 | 6-([(3R,5S)-5-][[[[(6-amino-4-methylpyridin-2-yl)methoxy]methyl]pyrrolidin-3-yl]oxy]methyl)-4-methylpyridin-2-amine |
compound impedes the growth of Bacillus subtilis under oxidative stress |
|
| 1.14.14.47 | 6-[5-([4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]oxy)pentyl]-4-methylpyridin-2-amine |
binding is stabilized by a 3.2 A H-bond between the pyrrolidine ring and the carbonyl group of tetrahydrobiopterin |
|
| 1.14.14.47 | 7-nitroindazole |
- |
|
| 1.14.14.47 | N,N'-[[(2S)-3-aminopropane-1,2-diyl]bis(oxymethylene-3,1-phenylene)]di(thiophene-2-carboximidamide) |
inhibitor binds by extending outside the active site to interact with a surface adjacent to residue Y357 |
|
