EC Number   |
Inhibitors |
Structure |
|---|
    1.14.14.139 | 5beta-cholestane-3alpha,7alpha,12alpha-triol |
0.066 mM, 62% inhibition |
   |
| 1.14.14.139 | 5beta-cholestane-3alpha,7alpha-diol |
0.066 mM, 30% inhibition |
|
| 1.14.14.139 | Emulgen 913 |
0.1% w/v, complete inhibition |
|
| 1.14.14.139 | MgCl2 |
1 mM, 10% inhibition |
|
| 1.14.14.139 | more |
cholic acid suppresses expression of CYP8B1 |
|
| 1.14.14.139 | more |
cholate supresses enzyme expression |
|
| 1.14.14.139 | more |
feeding of cholic acid suppresses expression of CYP8B1, the effect is partly reversed by taurine, feeding of taurine alone has no effect on enzyme expression |
|
| 1.14.14.139 | more |
feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 |
|
| 1.14.14.139 | more |
thyroid hormone triiodothyronine, i.e. T3, supresses enzyme expression in vivo |
|
| 1.14.14.139 | more |
the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor |
|
