EC Number |
Inhibitors |
Structure |
---|
1.14.11.48 | 6,8-dihydroxypurine |
slow-binding competitive inhibitor |
|
1.14.11.48 | 6,8-dihydroxypurine |
0.08 mM, 24% decrease in activity |
|
1.14.11.48 | Co2+ |
0.04 mM, about 65% inhibition |
|
1.14.11.48 | Cu2+ |
0.04 mM, complete inhibition |
|
1.14.11.48 | EDTA |
- |
|
1.14.11.48 | Fe2+ |
depending on the experimental conditions, Fe2+ concentrations of above 0.025 mM can lead to enzyme inhibition of the recombinant enzyme isolated from Escherichia coli, whereas the enzyme from Aspergillus nidulans is not inhibited at Fe2+ concentrations up to 0.080 mM |
|
1.14.11.48 | Mn2+ |
0.04 mM, about 80% inhibition |
|
1.14.11.48 | N-oxalylglycine |
competes with 2-oxoglutarate |
|
1.14.11.48 | NaCl |
0.5 M NaCl increases the Km of 2-oxoglutarate, increases the Km of xanthine and decreased the kcat |
|
1.14.11.48 | NaCl |
decrease of up to 46% in the relative activity in presence of 0.8 M NaCl |
|