EC Number   |
Inhibitors |
Structure |
|---|
    1.13.11.57 | 2,2'-dipyridyl |
2 mM 2,2'-dipyridyl, a specific Fe2+-chelator, abolishes the gallate dioxygenase activity completely |
   |
| 1.13.11.57 | 2-Methoxy-4-methylphenol |
20.8% inhibition at 5 mM |
|
| 1.13.11.57 | 4-nitrocatechol |
36.6% inhibition when the inhibitor is present in 5fold excess over substrate |
|
| 1.13.11.57 | 4-nitrocatechol |
31.6% inhibition at 5 mM |
|
| 1.13.11.57 | EDTA |
complete inhibition at 0.5 mM, the oxygen consumption activity after EDTA treatment is completely recovered by addition of Fe2+ (119%) |
|
| 1.13.11.57 | EDTA |
complete inhibition at 1 mM, the activity is only fully recovered with Fe2+ |
|
| 1.13.11.57 | H2O2 |
hydrogen peroxide at 1 mM reduces the gallate dioxygenase activity to 15%, and the activity can be partially restored (50% activity of the untreated enzyme) upon addition of 10 mM ascorbate |
|
| 1.13.11.57 | protocatechuate |
most potent inhibitor with mixed (competitive and non-competitive) inhibition profile, 49% inhibition at 5 mM |
|
| 1.13.11.57 | syringaldehyde |
least potent inhibitor, 8.66% inhibition at 5 mM |
|
| 1.13.11.57 | syringate |
16.3% inhibition at 5 mM |
|
