EC Number   |
Inhibitors |
Structure |
|---|
   1.11.1.10 | 5-vinyl-2-oxazolidinethione |
- |
   |
| 1.11.1.10 | azide |
- |
|
| 1.11.1.10 | azide |
active site ligand and inhibitor. At pH 4.0, supra-micromolar concentrations of azide inhibit the enzyme activity |
|
| 1.11.1.10 | cyanide |
- |
|
| 1.11.1.10 | diethyl dicarbonate |
the covalent modification of His105 inhibits the epoxidation and peroxide dismutations catalyzed by CPO |
|
| 1.11.1.10 | dimethyl dicarbonate |
the covalent modification of His105 inhibits the epoxidation and peroxide dismutations catalyzed by CPO |
|
| 1.11.1.10 | F- |
- |
|
| 1.11.1.10 | hydrogen peroxide |
the main process leading to peroxide-mediated enzyme inactivation is heme destruction (all tryptophan residues are partially oxidized in the inactive protein). 80000 molar equivalents of hydrogen peroxide are sufficient to reduce the activity of CPO to less than 5% |
|
| 1.11.1.10 | more |
not inhibited by sodium cyanoborohydride in molar excess of 1:10 and 1:100 |
|
| 1.11.1.10 | Sodium cyanoborohydride |
activity decreases in 38.2 and 92.6% for sodium cyanoborohydride molar excess of 1:1000 and 1:10000 |
|
