EC Number |
Inhibitors |
Structure |
---|
1.1.1.62 | (10R,13S,17R)-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5',6(4'H)-trione |
0.003 mM, 45% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (10R,13S,17R)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione |
0.003 mM, 61% inhibition, substrate: 4-androstene-3,17-dione; 0.003 mM, 63% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13alpha)-3-hydroxyestra-1(10),2,4-trien-17-one |
inhibits the enzyme activity effectively, enzyme affinity is similar to that of the natural estrone substrate |
|
1.1.1.62 | (13S,17R)-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'-diol |
0.003 mM, 61% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13S,17R)-3-hydroxy-13-methyl-3',4',6,7,8,9,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'-one |
0.003 mM, 79% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13S,17R)-3-hydroxy-13-methyl-5'-propyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one |
0.003 mM, 83% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13S,17R)-3-hydroxy-5',13-dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one |
0.003 mM, 94% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13S,17R)-5',13-dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one |
0.003 mM, 94% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13S,17R)-5',5',13-trimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one |
0.003 mM, 95% inhibition, substrate: 4-androstene-3,17-dione |
|
1.1.1.62 | (13S,17S)-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one |
0.003 mM, 95% inhibition, substrate: 4-androstene-3,17-dione |
|