EC Number |
Inhibitors |
Structure |
---|
1.1.1.357 | (3,6-dihydropyridin-1(2H)-yl)(1H-indol-2-yl)methanone |
crystal structure analysis of enzyme-inhibitor complex |
|
1.1.1.357 | (5-methyl-1H-indol-2-yl)(4-propylpiperidin-1-yl)methanone |
crystal structure analysis of enzyme-inhibitor complex |
|
1.1.1.357 | 17beta-estradiol |
competitive inhibitor |
|
1.1.1.357 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane |
hydroxychlor (HPTE), competitive without cofactor but mixed-type inhibition with cofactor, methoxychlor and its metabolite HPTE inhibit rat neurosteroidogenic 3alpha-hydroxysteroid dehydrogenase |
|
1.1.1.357 | 3,5,3',5'-tetraiodothyropropionic acid |
competitive inhibitor |
|
1.1.1.357 | 3-pentyl-2-[[(pyridin-2-yl)methyl]sulfanyl]-7-(pyrrolidine-1-carbonyl)quinazolin-4(3H)-one |
crystal structure analysis of enzyme-inhibitor complex |
|
1.1.1.357 | 4-chloro-N-[(4-chlorophenyl)methyl]-5-nitro-1H-pyrazole-3-carboxamide |
crystal structure analysis of enzyme-inhibitor complex |
|
1.1.1.357 | 4-nitro-2-([4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl)phenol |
crystal structure analysis of enzyme-inhibitor complex |
|
1.1.1.357 | 5-(benzenesulfonyl)-2-nitrophenol |
crystal structure analysis of enzyme-inhibitor complex |
|
1.1.1.357 | apigenin |
about 90% inhibition at 0.1 mM, inhibition kinetics. Apigenin inhibits AKR1C9 in a mixed-type inhibitory mode when the cofactor is used. This indicates that apigenin also affects the cofactor-binding site besides its binding to the active site of the steroid substrate. Docking analysis of the binding of apigenin to rat AKR1C9 with bound NADPH and substrate dihydrotestsosterone |
|