EC Number |
Inhibitors |
Structure |
---|
1.1.1.284 | 1,10-phenanthroline |
1 mM, 30% inhibition |
|
1.1.1.284 | 12-oxododecanoic acid |
substrate inhibition |
|
1.1.1.284 | 12-oxododecanoic acid |
linear competitive |
|
1.1.1.284 | 2,2'-dipyridyl |
1 mM, 20% inhibition |
|
1.1.1.284 | 2-mercaptoethanol |
inhibits both the reductase and dehydrogenase reactions by 30% at 1 mM |
|
1.1.1.284 | 3-(1-tert-butyl-4-amino-1H-indazol-3-yl)phenol |
CBR1 inhibitor, does not inhibit NADH-dependent S-nitrosoglutathione reduction |
|
1.1.1.284 | 3-(5-(4-(1H-imidazol-1-yl) phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl) propionic acid |
N6022, a specific and potent GSNO-R inhibitor. N6022 inhibits the GSNO-R-mediated metabolism of GSNO and formaldehyde in the heart |
|
1.1.1.284 | 3-(5-(4-(1H-imidazol-1-yl) phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl) propionic acid |
N6022, a commercial potent and specific inhibitor of GSNOR |
|
1.1.1.284 | 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid |
exhibits noncompetitive or uncompetitive inhibition against varied concentrations of S-nitrosoglutathione or NADH |
|
1.1.1.284 | 3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid |
3-[1-(4-acetylphenyl)-5-phenyl-1H-pyrrol-2-yl]propanoic acid and 4-([2-[(2-cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl)benzoic acid are more effective than 5-chloro-3-[2-[(4-ethoxyphenyl)(ethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid in inhibiting GSNOR inside the cells, dependence of S-nitrosothiols accumulation on the concentration of compound |
|