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EC Number
Inhibitors
Commentary
Structure
1.1.1.278
2-mercaptoethanol
activates at 1 mM, inhibitory at 10 mM
1.1.1.278
5alpha-pregnan-3,20-dione
-
1.1.1.278
ascorbate
-
1.1.1.278
Ca2+
-
1.1.1.278
Co2+
-
1.1.1.278
L-cysteine
1 mM, together with 2-mercaptoethanl, up to 50% inhibition
1.1.1.278
Mg2+
-
1.1.1.278
Mn2+
-
1.1.1.278
more
presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity
1.1.1.278
NADPH
inhibitory at concentrations above 1 mM
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