EC Number |
Inhibitors |
Structure |
---|
1.1.1.21 | ((1-(2H-tetrazol-5-yl)methyl)-1H-pyrrol-3-yl)(phenyl)-methanone |
40% inhibition |
|
1.1.1.21 | ((3aR,4R,6S,6aR)-6-((Z)-(((4-hydroperoxybenzyl)oxy)imino)methyl)-4-hydroxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 3-chlorobenzoate |
83% inhibition at 0.1 mM, oxyimino derivative, obtained by reaction of a 1,5-dicarbonyl substrate with O-(arylmethyl)hydroxylamine. Inhibitor reduces both cell death and the apoptotic process when tested in an in vitro model of diabetic retinopathy |
|
1.1.1.21 | (1,1-dihydroxy-3-oxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)acetic acid |
i.e. BiT, 1,1-dioxide-benzo[d]isothiazol-3-one alkanoic acid derivatives |
|
1.1.1.21 | (1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid |
IC50: 0.010 mM |
|
1.1.1.21 | (1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid ethyl ester |
- |
|
1.1.1.21 | (1,3,3-trioxo-2,3-dihydronaphtho[2,3-d]isothiazol-2-yl)acetic acid ethyl ester |
- |
|
1.1.1.21 | (1-(2-(2H-tetrazol-5-yl)ethyl)-1H-pyrrol-3-yl)(phenyl)-methanone |
6% inhibition |
|
1.1.1.21 | (1-(2H-tetrazole-5-yl)-1H-pyrrol-2-yl)(phenyl)-methanone |
- |
|
1.1.1.21 | (1-(2H-tetrazole-5-yl)-1H-pyrrol-3-yl)(phenyl)-methanone |
- |
|
1.1.1.21 | (1-(3-(2H-tetrazol-5-yl)propyl)-1H-pyrrol-3-yl)(phenyl)-methanone |
41% inhibition |
|