Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Inhibitors

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search
Image of 2D Structure
Search for synonyms (with exact matching search term)

Search term:

Results 1 - 7 of 7
EC Number Inhibitors Commentary Structure
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1705alpha-cholest-7-en-3-one 2-9.3% inhibition between 16 and 130 nmol Go to the Ligand Summary Page
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.1705alpha-Cholest-7-en-3beta-ol 15.5-65% inhibition between 30 and 260 nmol Go to the Ligand Summary Page
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.170Fe2+ less than 25% inhibition at 1 mM Go to the Ligand Summary Page
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.170FR171456 a natural specific inhibitor of yeast Erg26p from Monodictys sp.. FR171456 is a natural product with cholesterol-lowering properties in animal models. FR171456 significantly alters the levels of cholesterol pathway intermediates in yeast cells. FR171456 causes significant growth inhibition of strain SC5314 at. Erg26p inhibition requires the 4alpha-carboxyl group of FR171456, substitution of the 4alpha-carboxylic group of FR171456 by a carbobenzylamido group (Compound-1) decreases inhibition Go to the Ligand Summary Page
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.170FR171456 a natural specific inhibitor of mammalian NSDHL from Monodictys sp.. FR171456 is a natural product with cholesterol-lowering properties in animal models. FR171456 significantly alters the levels of cholesterol pathway intermediates in human cells. R171456 inhibits an artificial Hepatitis C viral replicon, and has broad antifungal activity, suggesting potential additional utility as an anti-infective. In a screen to profile compound activity against 503 cancer cell lines only five cell lines are sensitive to FR171456 with IC50 values below 0.005 mM. Calcidiol, a cholesterol metabolite situated downstream of NSDHL, is decreased in a FR171456 dose-dependent manner, consistent with a reduction of cholesterol synthesis, and new derivatives of NSDHL substrates are deteremined in the cells that are no longer effective as substrates Go to the Ligand Summary Page
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.170FR171456 a natural specific inhibitor of yeast Erg26p from Monodictys sp.. Genomic profiling identifies Erg26p as the FR171456 target, the ERG26 heterozygous strain (erg26DELTA/ERG26) shows the most significant hypersensitivity to FR171456. FR171456 is a natural product with cholesterol-lowering properties in animal models. FR171456 significantly alters the levels of cholesterol pathway intermediates in yeast cells. FR171456 causes significant growth inhibition of strain BY4743 at concentrations up to 0.2 mM. Multiple mutations, e.g. Gly90Ser, in enzyme ERG26 confer resistance to FR171456 in growth and enzyme assays. FR171456 inhibits an artificial Hepatitis C viral replicon, and has broad antifungal activity, suggesting potential additional utility as an anti-infective. Erg26p inhibition requires the 4a-carboxyl group of FR171456, substitution of the 4alpha-carboxylic group of FR171456 by a carbobenzylamido group (Compound-1) decreases inhibition by 300fold. FR171456 docking into a homology model of Erg26p. Modelling FR171456 resistance mutations on Erg26p, overview Go to the Ligand Summary Page
Show all pathways known for 1.1.1.170Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.170Zn2+ marked inhibition between 0.1 and 1 mM Go to the Ligand Summary Page
Results 1 - 7 of 7