EC Number |
Inhibitors |
Structure |
---|
4.3.2.2 | 2'-deoxy-AMP |
- |
|
4.3.2.2 | 2'-deoxy-AMP |
competitive |
|
4.3.2.2 | 4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate |
- |
|
4.3.2.2 | 5-aminoimidazole-4-carboxamide ribonucleoside |
50% inhibition at 0.167 mM |
|
4.3.2.2 | 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate |
i.e. ZMP or AICAR, product inhibition, accumulation in the brain of Lesch-Nyhan disease patients induces inhibition of mitochondrial oxidative phosphorylation and adenylosuccinate lyase activity, followed by dowregulation of ATP levels and multifocal cell death in the cerebellum |
|
4.3.2.2 | 8-Aza-AMP |
- |
|
4.3.2.2 | adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate |
i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits negative cooperativity. Binding to enzyme mutants, overview |
|
4.3.2.2 | adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate |
i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits positive cooperativity |
|
4.3.2.2 | adenosine phosphonobutyric, 2'(3'), 5'-diposphate |
- |
|
4.3.2.2 | adenyloethylphosphonate |
- |
|