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Results 1 - 10 of 59 > >>
EC Number
Inhibitors
Commentary
Structure
2'-deoxy-AMP
-
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2'-deoxy-AMP
competitive
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4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate
-
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5-aminoimidazole-4-carboxamide ribonucleoside
50% inhibition at 0.167 mM
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5-aminoimidazole-4-carboxamide riboside 5'-monophosphate
i.e. ZMP or AICAR, product inhibition, accumulation in the brain of Lesch-Nyhan disease patients induces inhibition of mitochondrial oxidative phosphorylation and adenylosuccinate lyase activity, followed by dowregulation of ATP levels and multifocal cell death in the cerebellum
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8-Aza-AMP
-
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adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate
i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits negative cooperativity. Binding to enzyme mutants, overview
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adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate
i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits positive cooperativity
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adenosine phosphonobutyric, 2'(3'), 5'-diposphate
-
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adenyloethylphosphonate
-
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Results 1 - 10 of 59 > >>