EC Number |
Inhibitors |
Structure |
---|
3.1.11.2 | DNA |
urea-containg DNA is a competitive inhibitor when apurinic DNA is used as substrate, apurinic DNA inhibits when urea-containing DNA is used as substrate |
|
3.1.11.2 | DNA |
- |
|
3.1.11.2 | EDTA |
- |
|
3.1.11.2 | Mn2+ |
at concentrations above 5 mM |
|
3.1.11.2 | more |
while a clamp-specific inhibitor can disrupt the beta-clamp-XthA complex, a proliferating cell nuclear antigen (PCNA)-specific inhibitor is not able to do so |
|
3.1.11.2 | NaCl |
no activity above 300 mM |
|
3.1.11.2 | NaCl |
addition of more than 200 mM salt, strongly inhibits the endonuclease activity |
|
3.1.11.2 | p-chloromercuribenzoate |
50% inhibition of DNA phosphatase activity, 90% loss of exonuclease activity |
|
3.1.11.2 | PNA |
anti-parallel complementary PNA suppresses the degradation of double-stranded DNA by enzyme and the suppression is dependent on the amount and concentration of the PNA |
|
3.1.11.2 | ZnCl2 |
0.03 mM, 95% inhibition |
|