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EC Number
Inhibitors
Commentary
Structure
3.1.11.2
DNA
-
3.1.11.2
EDTA
-
3.1.11.2
ZnCl2
0.03 mM, 90% inhibition of DNA phosphatase activity and 88% loss of exonuclease activity
3.1.11.2
ZnCl2
0.03 mM, 95% inhibition
3.1.11.2
p-chloromercuribenzoate
50% inhibition of DNA phosphatase activity, 90% loss of exonuclease activity
3.1.11.2
NaCl
addition of more than 200 mM salt, strongly inhibits the endonuclease activity
3.1.11.2
PNA
anti-parallel complementary PNA suppresses the degradation of double-stranded DNA by enzyme and the suppression is dependent on the amount and concentration of the PNA
3.1.11.2
Mn2+
at concentrations above 5 mM
3.1.11.2
NaCl
no activity above 300 mM
3.1.11.2
DNA
urea-containg DNA is a competitive inhibitor when apurinic DNA is used as substrate, apurinic DNA inhibits when urea-containing DNA is used as substrate
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