EC Number |
Inhibitors |
Structure |
---|
2.7.4.8 | more |
GMP-phosphorylation is less sensitive to metal ions than dGMP-phosphorylation; minimal inactivation by iodoacetate and iodoacetamide not affected by the presence or absence of KCl; no inhibition by 2-mercaptoethanol, 1,4-dithiothreitol |
|
2.7.4.8 | more |
no inhibition by 2-mercaptoethanol, 1,4-dithiothreitol; no inhibition by guanosine, AMP, CMP, UMP, XMP, 6-thioinosine 5'-phosphate |
|
2.7.4.8 | more |
guanylic nucleotides strongly inhibit, compete with GMP |
|
2.7.4.8 | more |
no inhibition by 9-(5-phosphonopentyl)guanine (i.e. isosteric analogue of acyclovir 5'-monophosphate) |
|
2.7.4.8 | more |
no inhibition by TMP and by 2-mercaptoethanol up to 5 mM |
|
2.7.4.8 | more |
no inhibition of the cytosolic isozyme by guanosine 3',5'-bisdiphosphate |
|
2.7.4.8 | more |
no or poor inhibition by sulfhydryl group inhibitors p-chloromercuribenzoate and N-ethylmaleimide, reducing agents (DTT and BME) and His modification by diethyl dicarbonate. No or poor inhibition by DEC, ivermectin and levamisole |
|
2.7.4.8 | more |
in silico identification of novel antagonists and binding insights by structural and functional analyses of guanylate kinase of Leishmania donovani and interaction with inhibitors |
|
2.7.4.8 | ATP |
- |
|
2.7.4.8 | ATP |
free form, substrate inhibition, competitive toward MgATP2- |
|