EC Number |
Inhibitors |
Structure |
---|
2.7.2.1 | more |
not inactivated by 5,5'-dithiobis(2-nitrobenzoic acid), tetranitromethane or 2-hydroxy-3-nitro-benzyl bromide |
|
2.7.2.1 | more |
not inactivated by N-ethylmaleimide |
|
2.7.2.1 | more |
5,5'-dithiobis(2-nitrobenzoic acid), p-chloromercuriphenylsulfonate, N-ethylmaleimide and phenylglyoxal does not affect the enzyme activity |
|
2.7.2.1 | more |
iodoacetate and iodoacetamide does not inhibit |
|
2.7.2.1 | more |
preincubation with butyrate does not significantly inhibit the enzyme |
|
2.7.2.1 | more |
inhibitor design using the the structure of the catalytic intermediate |
|
2.7.2.1 | more |
not inhibited by eugenyl acetate and pinoresinol |
|
2.7.2.1 | more |
not inhibited by phosphate |
|
2.7.2.1 | ADP |
- |
|
2.7.2.1 | ADP |
inhibition by preincubation with MgCl2, ADP, AlCl3, NaF, and acetate. When MgCl2, ADP, and acetate are omitted from the preincubation mixture, there is no detectable loss of activity; inhibition of acetate kinase by preincubation with MgCl2, ADP, AlCl3, NaF, and acetate (all of the components are necessary for maximum inhibition). The transition state analog, MgADP-aluminum fluoride-acetate, forms an abortive complex in the active site |
|