EC Number   |
Inhibitors |
Structure |
|---|
   2.3.2.23 | 1-(1,3-benzothiazol-2-yl)methanamine |
i.e. EM04, about 40% inhibition of FANCD2 ubiquination |
   |
| 2.3.2.23 | 2-amino-5-phenylfuran-3-carbonitrile |
i.e. EM11, about 25% inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | 2alpha,6alpha-diacetoxy-4beta-hydroxy-11(13)-pseudoguaien-12,8alpha-olide |
inhibitor directly binds to UbcH5c protein and inhibits cell viability and colony formation, induces apoptosis, and suppresses migration and invasion of pancreatic cancer cells in vitro. The compound inhibits UbcH5c-mediated IkappaBalpha degradation and NF-kappaB activation. The compound suppresses the tumor growth and metastasis in two orthotopic pancreatic tumor mouse models |
|
| 2.3.2.23 | 3-(2-hydroxyphenyl)pyridin-2(1H)-one |
- |
|
| 2.3.2.23 | 3-methyl-3,4-dihydroquinazolin-2(1H)-one |
i.e. EM09, about 15% inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | 4-phenyl-1,3-thiazol-2-amine |
i.e. EM17, about 60% inhibition of FANCD2 ubiquination |
|
| 2.3.2.23 | 5,6-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione |
- |
|
| 2.3.2.23 | 5-([4-[(thiophen-2-yl)acetyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
- |
|
| 2.3.2.23 | 5-([4-[2-(thiophen-2-yl)ethyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
- |
|
| 2.3.2.23 | 5-benzylpyrazolo[1,5-a]pyrimidin-7(4H)-one |
- |
|
