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Results 1 - 10 of 52 > >>
EC Number
Inhibitors
Commentary
Structure
(E)-1-(4-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one
80% residual activity
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(E)-2-nitrophenyl cinnamate
-
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(E)-3-phenoxybenzyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate
61% residual activity
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(E)-4-cyanophenyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate
-
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(E)-benzyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate
71% residual activity
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(E)-phenyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate
69% residual activity
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1,2,3,4,6-penta-O-galloyl-beta-D-glucose
mixed type of inhibition. IC50 value 0.9 microgramm per ml, Ki value 0.21 microgramm per ml
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1,2,3,4,6-penta-O-galloyl-beta-D-glucose
minimal inhibitory concentration 0.125 mg/ml
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1,2,3,4,6-penta-O-galloyl-beta-D-glucose
minimal inhibitory concentration 0.25 mg/ml
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1,2,3,4,6-penta-O-galloyl-beta-D-glucose
compound is transported across cancer cell membrane to further down-regulate FAS and activate caspase-3 in MDA-MB-231 cells. Compared with other FAS inhibitors, including catechin gallate and morin, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose involves a higher reversible fast-binding inhibition with an irreversible slow-binding inhibition, i.e. saturation kinetics with a dissociation constant of 0.59 microM and a limiting rate constant of 0.16 per min. The major reacting site of PGG is on the beta-ketoacyl reduction domain of FAS. Compound exhibits different types of inhibitions against the three substrates in the FAS overall reaction
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Results 1 - 10 of 52 > >>