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EC Number
Inhibitors
Commentary
Structure
2.5.1.21
YM-53601
-
2.5.1.21
zaragozic acid
IC50 0.7 nM
2.5.1.21
zaragozic acid
competitive to farnesyl diphosphate
2.5.1.21
zaragozic acid
hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid
2.5.1.21
zaragozic acid
-
2.5.1.21
zaragozic acid
decrease in plasma cholesterol
2.5.1.21
zaragozic acid
competitive type of inhibition
2.5.1.21
zaragozic acid
potent inhibitor
2.5.1.21
zaragozic acid A
0.04 mM
2.5.1.21
zaragozic acid A
inhibition of squalene synthase. Administration also significantly increases the rate of degradation of hepatic low density lipoprotein receptor protein, and increases proprotein convertase subtilisin/kexin type 9 mRNA and protein levels in concert with an increase in hepatic low density lipoprotein receptor mRNA levels, low density lipoprotein turnover, and decreases in serum cholesterol levels
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