EC Number   |
Inhibitors |
Structure |
|---|
    2.4.2.17 | 2-[(2-bromo-3,5-dinitrophenyl)carbonyl]-N-phenylhydrazinecarboxamide |
has whole-cell activity at 0.025 mM |
   |
| 2.4.2.17 | 4-methoxybenzyl 2-methyl-5-oxo-4,7-dithiophen-2-yl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate |
interacts with the phosphoribosyl diphosphate binding site but less strongly compared to compound 6 , exhibits greater than 50% inhibition at 0.01 mM |
|
| 2.4.2.17 | 5-phospho-alpha-D-ribose 1-diphosphate |
noncompetitive inhibitor with respect to both substrates in the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate |
|
| 2.4.2.17 | adenine |
competitive to ATP and 5-phospho-alpha-D-ribose 1-diphosphate |
|
| 2.4.2.17 | ADP |
competitive to ATP, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent |
|
| 2.4.2.17 | ADP |
- |
|
| 2.4.2.17 | ADP |
competitive to ATP |
|
| 2.4.2.17 | ADP |
orthosteric inhibition |
|
| 2.4.2.17 | Ag+ |
- |
|
| 2.4.2.17 | AMP |
competitive inhibitor to 5-phospho-alpha-D-ribose 1-diphosphate, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent |
|
