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<< < Results 21 - 26 of 26
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.232alpha,6alpha-diacetoxy-4beta-hydroxy-11(13)-pseudoguaien-12,8alpha-olide inhibitor directly binds to UbcH5c protein and inhibits cell viability and colony formation, induces apoptosis, and suppresses migration and invasion of pancreatic cancer cells in vitro. The compound inhibits UbcH5c-mediated IkappaBalpha degradation and NF-kappaB activation. The compound suppresses the tumor growth and metastasis in two orthotopic pancreatic tumor mouse models Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.235-([4-[(thiophen-2-yl)acetyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.235-([4-[2-(thiophen-2-yl)ethyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.235-benzylpyrazolo[1,5-a]pyrimidin-7(4H)-one - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.235-[(piperidin-1-yl)methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.23eupalinolide B Kd value 0.00925 mM. UBE2D3 is modified by EB in residue Cys85, the presence of eupalinolide B enhances the thermal stabilization of UBE2D3. Eupanolide B effectively inhibits the activity of UBE2D3 and prevents the degradation of IkappaBalpha and the activation of NF-kappaB Go to the Ligand Summary Page
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