EC Number   |
Inhibitors |
Structure  |
|---|
   2.3.2.23 | 3-methyl-3,4-dihydroquinazolin-2(1H)-one |
i.e. EM09, about 15% inhibition of FANCD2 ubiquination |
   |
| 2.3.2.23 | 5-chloro-1,3-benzoxazole-2-thiol |
- |
|
| 2.3.2.23 | 6-chloro-1,3-benzoxazole-2-thiol |
- |
|
| 2.3.2.23 | ethyl 3-(2,2'-dihydroxy[1,1'-biphenyl]-4-yl)propanoate |
- |
|
| 2.3.2.23 | [1,1'-biphenyl]-2,2'-diol |
- |
|
| 2.3.2.23 | [1,1'-biphenyl]-2-ol |
- |
|
| 2.3.2.23 | [1,1'-biphenyl]-2-sulfonamide |
- |
|
| 2.3.2.23 | 5,6-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione |
- |
|
| 2.3.2.23 | CC0651 |
a small-molecule inhibitor that selectively inhibits Ube2R1, the specialized E2 for SCF E3 ligases, which builds K48-linked polyUb chains on its targets for proteasomal degradation. In a co-crystal structure of Ube2R1, Ub, and CC0651, the inhibitor is sandwiched between the E2 and Ub |
|
| 2.3.2.23 | CC0651 |
- |
|
