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EC Number	General Stability	Reference
3.4.24.17	Ca2+ is required to maintain the active conformation, full activity is detected at 1 mM Ca2+, at pH 7.5 and is retained at even higher concentrations of Ca2+, at lower concentrations the enzyme is autolyzed	31017
3.4.24.17	Ca2+ stabilizes	31012, 31017
3.4.24.17	catalytic domain of MMP-12 exhibits higher activity, more rigidity of its backbone, and lower folding stability than its counterpart of theMMP-3 catalytic domain that has more internal motions throughout	717387

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Release 2023.1 (January 2023)