EC Number   |
Activating Compound |
Reference |
|---|
    6.3.4.14 | acetyl-CoA |
allosteric activator of holoenzyme. Acetyl-CoA promotes a conformation for the dimer of the biotin carboxylase domain of pyruvate carboxylase that might be catalytically more competent |
706790 |
| 6.3.4.14 | biotin |
activates the ATP synthesis reaction with ADP and carbamoyl phosphate as substrates |
654575, 656008 |
| 6.3.4.14 | biotin |
required for activation of the ATP synthesis reaction with carbamoyl phosphate and ADP as substrates, E211, E288, N290 and R292 are responsible, at least in part, for the substrate-induced synergism by biotin, activation via a conformational change of enzyme |
654566 |
| 6.3.4.14 | biotin |
substrate induced synergism, the reaction inpresence of biotin is 1100fold faster than in its absence |
695008 |
| 6.3.4.14 | biotin |
substrate-induced synergism, the reaction in presence of biotin is 1100fold faster than in its absence |
695008 |
| 6.3.4.14 | cyclophilin |
cyclophilin stimulates the ATP hydrolysis activity of the enzyme (8fold stimulation of activity at 10fold molar excess over the enzyme) |
726872 |
| 6.3.4.14 | ethanol |
maximal activation, 10fold, at 15% v/v. Inactivation at 20% v/v |
1426 |
| 6.3.4.14 | ethanol |
maximal activation, 11fold at 15% |
1428 |
