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EC Number Activating Compound Commentary Reference
Display the reaction diagram Show all sequences 6.3.1.4more ASNS is induced by ATF4, amino acid deprivation, or ER stress, siRNA-mediated knockdown of CHOP further enhances the induction of ASNS by either amino acid deprivation or ER stress, overview 693193
Display the reaction diagram Show all sequences 6.3.1.4more the unfolded protein response, UPR, pathway is comprised of three signaling cascades, mediated by the ER stress sensor proteins PERK, IRE1, and ATF6, and PERK is responsible for activation of the ASNS, while the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview 690840
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